ReviewChild development
DNA methylation: a mechanism for embedding early life experiences in the genome.
Review in Child development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
116 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The association between prenatal famine, DNA methylation and mental disorders: a systematic review and meta-analysis.Clinical epigenetics · 2023Pooled it
- Epigenetics in eating disorders: a systematic review.Molecular psychiatry · 2019Pooled it
- Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms.Clinical child and family psychology review · 2015Pooled it
- Effects of improved on-farm crop storage on DNA methylation of mothers and their infants: evidence from a randomized controlled trial in Kenya.Clinical epigenetics · 2024Trial
- An investigation of child maltreatment and epigenetic mechanisms of mental and physical health risk.Development and psychopathology · 2016Trial
- Genome-wide DNA methylation in 1-year-old infants of mothers with major depressive disorder.Development and psychopathology · 2016Trial
- Epigenetic Changes Associated With a Phenotypic Transition in Namibian Cheetahs.Molecular ecology · 2026Article
- Biological, genetic, neurological and environmental influences on homosexuality-a narrative review.Frontiers in behavioral neuroscience · 2025Review
- Differential methylation of OPRK1 in borderline personality disorder is associated with childhood trauma.Molecular psychiatry · 2024Article
- Trauma context exerts intergenerational effects on child mental health via DNA methylation.Epigenetics · 2024Article
- DNA methylation as a possible mechanism linking childhood adversity and health: results from a 2-sample mendelian randomization study.American journal of epidemiology · 2024Article
- GWAS of biological aging to find longevity genes in schizophrenia.European archives of psychiatry and clinical neuroscience · 2024Article
- A preliminary investigation of epigenome-wide DNA methylation and temperament during infancy.Developmental psychobiology · 2024Article
- Epigenetic signatures of social status in wild female spotted hyenas (Crocuta crocuta).Communications biology · 2024Article
- Blood epigenome-wide association studies of suicide attempt in adults with bipolar disorder.Translational psychiatry · 2024Article
- Epigenetics of Fear, Anxiety and Stress - Focus on Histone Modifications.Current neuropharmacology · 2024Article
- How life events may confer vulnerability to addiction: the role of epigenetics.Frontiers in molecular neuroscience · 2024Review
- Stress-related cellular pathophysiology as a crosstalk risk factor for neurocognitive and psychiatric disorders.BMC neuroscience · 2023Review
- The Val158Met Polymorphism in 8-Year-Old Boys and Girls Moderates the Influence of Parenting Styles on Proactive Aggression: Testing the Sensitivity to the Environment.Brain sciences · 2023Article
- Stress before conception and during pregnancy and maternal cortisol during pregnancy: A scoping review.Psychoneuroendocrinology · 2023Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Although epidemiological data provide evidence that early life experience plays a critical role in human development, the mechanism of how this works remains in question. Recent data from human and animal literature suggest that epigenetic changes, such as DNA methylation, are involved not only in cellular differentiation but also in the modulation of genome function in response to early life experience affecting gene function and the phenotype. Such modulations may serve as a mechanism for life-long genome adaptation. These changes seem to be widely distributed across the genome and to involve central and peripheral systems. Examining the environmental circumstances associated with the onset and reversal of DNA methylation will be critical for understanding risk and resiliency.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.