ArticlePloS one2012
Functional gene-guided discovery of type II polyketides from culturable actinomycetes associated with soft coral Scleronephthya sp.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Mini review: antimicrobial compounds produced by bacteria associated with marine invertebrates.Folia microbiologica · 2025Review
- Marine Ascomycetes Extract Antifungal Susceptibility against Candida spp. Isolates from Oral Candidiasis HIV/AIDS Patient: An In Vitro Study.European journal of dentistry · 2024Article
- Maribacter halichondriae sp. nov., isolated from the marine sponge Halichondria panicea, displays features of a sponge-associated life style.Antonie van Leeuwenhoek · 2024Article
- Halo- and Thiocarbazomycins from Coral- and Coral Reef Sands-DerivedMarine drugs · 2022Article
- Natural Products from Actinomycetes Associated with Marine Organisms.Marine drugs · 2021Review
- Actinomycetes from the Red Sea SpongeMicroorganisms · 2020Article
- Impact ofFrontiers in microbiology · 2020Article
- Bioactive Secondary Metabolites from Octocoral-Associated Microbes-New Chances for Blue Growth.Marine drugs · 2018Review
- Recovering Genomics Clusters of Secondary Metabolites from Lakes Using Genome-Resolved Metagenomics.Frontiers in microbiology · 2018Article
- Antimicrobial potential and taxonomic investigation of piezotolerant Streptomyces sp. NIOT-Ch-40 isolated from deep-sea sediment.World journal of microbiology & biotechnology · 2017Article
- Pharmacological Potential of Phylogenetically Diverse Actinobacteria Isolated from Deep-Sea Coral Ecosystems of the Submarine Avilés Canyon in the Cantabrian Sea.Microbial ecology · 2017Article
- Metagenomic Analysis of Upwelling-Affected Brazilian Coastal Seawater Reveals Sequence Domains of Type I PKS and Modular NRPS.International journal of molecular sciences · 2015Article
- Two Streptomyces species producing antibiotic, antitumor, and anti-inflammatory compounds are widespread among intertidal macroalgae and deep-sea coral reef invertebrates from the central Cantabrian Sea.Microbial ecology · 2015Article
- Isolation and in vitro selection of actinomycetes strains as potential probiotics for aquaculture.Veterinary world · 2015Article
- Diversity and distribution of Actinobacteria associated with reef coral Porites lutea.Frontiers in microbiology · 2015Article
- Actinomycetes from Red Sea sponges: sources for chemical and phylogenetic diversity.Marine drugs · 2014Article
- Pyrosequencing reveals diverse microbial community associated with the zoanthid Palythoa australiae from the South China Sea.Microbial ecology · 2014Article
- Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides.Journal of industrial microbiology & biotechnology · 2014Review
- Phylogenetic diversity of actinobacteria associated with soft coral Alcyonium gracllimum and stony coral Tubastraea coccinea in the East China Sea.Microbial ecology · 2013Article
- Antimicrobial activity of heterotrophic bacterial communities from the marine sponge Erylus discophorus (Astrophorida, Geodiidae).PloS one · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Compared with the actinomycetes in stone corals, the phylogenetic diversity of soft coral-associated culturable actinomycetes is essentially unexplored. Meanwhile, the knowledge of the natural products from coral-associated actinomycetes is very limited. In this study, thirty-two strains were isolated from the tissue of the soft coral Scleronephthya sp. in the East China Sea, which were grouped into eight genera by 16S rDNA phylogenetic analysis: Micromonospora, Gordonia, Mycobacterium, Nocardioides, Streptomyces, Cellulomonas, Dietzia and Rhodococcus. 6 Micromonospora strains and 4 Streptomyces strains were found to be with the potential for producing aromatic polyketides based on the analysis of KS(α) (ketoacyl-synthase) gene in the PKS II (type II polyketides synthase) gene cluster. Among the 6 Micromonospora strains, angucycline cyclase gene was amplified in 2 strains (A5-1 and A6-2), suggesting their potential in synthesizing angucyclines e.g. jadomycin. Under the guidance of functional gene prediction, one jadomycin B analogue (7b, 13-dihydro-7-O-methyl jadomycin B) was detected in the fermentation broth of Micromonospora sp. strain A5-1. This study highlights the phylogenetically diverse culturable actinomycetes associated with the tissue of soft coral Scleronephthya sp. and the potential of coral-derived actinomycetes especially Micromonospora in producing aromatic polyketides.
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