Evidence map›Paper›PMID 22880108›Full record

Trial reportPloS one2012

The effect of exercise training modality on serum brain derived neurotrophic factor levels in individuals with type 2 diabetes.

Damon L Swift, Neil M Johannsen, Valerie H Myers, Conrad P Earnest, Jasper A J Smits, Steven N Blair, Timothy S Church

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00458133 (Health Benefits of Aerobic and Resistance Training in Individuals With Type 2 Diabetes), which is not on this map. Cited by 32 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 4 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00458133 nacompletednot on this map

Health Benefits of Aerobic and Resistance Training in Individuals With Type 2 Diabetes

TypeinterventionalSponsorPennington Biomedical Research CenterRan2007 to 2010Enrolled262ConditionsType 2 DiabetesArmsexercise
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Aquatic Exercise on Brain Activity in Type 2 Diabetic: Randomized Clinical Trial.International journal of environmental research and public health · 2022
    Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Damon L SwiftDepartment of Preventive Medicine, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America.
Neil M Johannsen
Valerie H Myers
Conrad P Earnest
Jasper A J Smits
Steven N Blair
Timothy S Church
Pennington Biomedical Research Center · USSouthern Methodist University · USUniversity of Bath · GBUniversity of South Carolina · US

Funding

Training in Obesity ResearchT32DK064584 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI CORBY K MARTIN, Christopher D Morrison · 2003 to 2026
$5.3M
Health benefits of Aerobic and Resistance Training in individuals with DiabetesR01DK068298 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI CHURCH, TIMOTHY STEPHEN · 2006 to 2009
$2.3M
NIDDK NIH HHS R01 DK068298NIDDK NIH HHS T32 DK064584NIDDK NIH HHS T32 DK 64584-9
6 · The paper itself

Abstract

introductionBrain derived neurotrophic factor (BDNF) has been implicated in memory, learning, and neurodegenerative diseases. However, the relationship of BDNF with cardiometabolic risk factors is unclear, and the effect of exercise training on BDNF has not been previously explored in individuals with type 2 diabetes.

methodsMen and women (N = 150) with type 2 diabetes were randomized to an aerobic exercise (aerobic), resistance exercise (resistance), or a combination of both (combination) for 9 months. Serum BDNF levels were evaluated at baseline and follow-up from archived blood samples.

resultsBaseline serum BDNF was not associated with fitness, body composition, anthropometry, glucose control, or strength measures (all, p>0.05). Similarly, no significant change in serum BDNF levels was observed following exercise training in the aerobic (-1649.4 pg/ml, CI: -4768.9 to 1470.2), resistance (-2351.2 pg/ml, CI:-5290.7 to 588.3), or combination groups (-827.4 pg/ml, CI: -3533.3 to 1878.5) compared to the control group (-2320.0 pg/ml, CI: -5750.8 to 1110.8). However, reductions in waist circumference were directly associated with changes in serum BDNF following training (r = 0.25, p = 0.005).

conclusionsSerum BDNF was not associated with fitness, body composition, anthropometry, glucose control, or strength measures at baseline. Likewise, serum BDNF measures were not altered by 9 months of aerobic, resistance, or combination training. However, reductions in waist circumference were associated with decreased serum BDNF levels. Future studies should investigate the relevance of BDNF with measures of cognitive function specifically in individuals with type-2 diabetes.

Indexed as

ExerciseExercise TestBrain-Derived Neurotrophic FactorCardiovascular DiseasesDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedRisk FactorsStatistics, NonparametricBrain-Derived Neurotrophic Factor

Identifiers

PMID22880108
PMCPMC3412800
OpenAlexW2055959964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.