ArticlePloS one2012
Genome-wide detection of spontaneous chromosomal rearrangements in bacteria.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Insights into Yersinia pestis evolution through rearrangement analysis of 242 complete genomes.Nature genetics · 2025Article
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- Tandem gene duplication selected by activation of horizontally transferred gene in bacteria.Applied microbiology and biotechnology · 2024Article
- Large-scale duplication events underpin population-level flexibility in tRNA gene copy number in Pseudomonas fluorescens SBW25.Nucleic acids research · 2024Article
- Attempts to limit sporulation in the probiotic strainAccess microbiology · 2023Article
- Comparative Genomics ofMicroorganisms · 2022Article
- Neural networks enable efficient and accurate simulation-based inference of evolutionary parameters from adaptation dynamics.PLoS biology · 2022Article
- Comparative genome analysis of fourComputational and structural biotechnology journal · 2022Article
- Genome structural variation inMicrobial genomics · 2021Article
- The highly dynamic nature of bacterial heteroresistance impairs its clinical detection.Communications biology · 2021Article
- Gene amplification as a form of population-level gene expression regulation.Nature ecology & evolution · 2020Article
- Complete Genome Sequence ofMicroorganisms · 2020Article
- Gene Duplications in the Genomes of Staphylococci and Enterococci.Frontiers in molecular biosciences · 2020Article
- Chromosome architecture constrains horizontal gene transfer in bacteria.PLoS genetics · 2018Article
- Gene Duplication in Pseudomonas aeruginosa Improves Growth on Adenosine.Journal of bacteriology · 2017Article
- Coevolution of the Organization and Structure of Prokaryotic Genomes.Cold Spring Harbor perspectives in biology · 2016Review
- Genome-wide analysis of myxobacterial two-component systems: genome relatedness and evolutionary changes.BMC genomics · 2015Article
- Large tandem chromosome expansions facilitate niche adaptation during persistent infection with drug-resistantMicrobial genomics · 2015Article
- Evolution of new functions de novo and from preexisting genes.Cold Spring Harbor perspectives in biology · 2015Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome rearrangements have important effects on bacterial phenotypes and influence the evolution of bacterial genomes. Conventional strategies for characterizing rearrangements in bacterial genomes rely on comparisons of sequenced genomes from related species. However, the spectra of spontaneous rearrangements in supposedly homogenous and clonal bacterial populations are still poorly characterized. Here we used 454 pyrosequencing technology and a 'split mapping' computational method to identify unique junction sequences caused by spontaneous genome rearrangements in chemostat cultures of Salmonella enterica Var. Typhimurium LT2. We confirmed 22 unique junction sequences with a junction microhomology more than 10 bp and this led to an estimation of 51 true junction sequences, of which 28, 12 and 11 were likely to be formed by deletion, duplication and inversion events, respectively. All experimentally confirmed rearrangements had short inverted (inversions) or direct (deletions and duplications) homologous repeat sequences at the endpoints. This study demonstrates the feasibility of genome wide characterization of spontaneous genome rearrangements in bacteria and the very high steady-state frequency (20-40%) of rearrangements in bacterial populations.
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