ArticlePloS one2012
FT-ICR/MS and GC-EI/MS metabolomics networking unravels global potato sprout's responses to Rhizoctonia solani infection.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 82 citations in OpenAlex.
- Potato Berries as a Valuable Source of Compounds Potentially Applicable in Crop Protection and Pharmaceutical Sectors: A Review.Journal of agricultural and food chemistry · 2024Review
- Transcriptome and metabolome analyses reveal the regulatory role of MdPYL9 in drought resistance in apple.BMC plant biology · 2024Article
- Metabolic profiles of peanut (Arachis hypogaea L.) in response to Puccinia arachidis fungal infection.BMC genomics · 2023Article
- Raman Multi-Omic Snapshots of Koshihikari Rice Kernels Reveal Important Molecular Diversities with Potential Benefits in Healthcare.Foods (Basel, Switzerland) · 2023Article
- Decoding Metabolic Reprogramming in Plants under Pathogen Attacks, a Comprehensive Review of Emerging Metabolomics Technologies to Maximize Their Applications.Metabolites · 2023Review
- Combined Transcriptomic and Metabolomic Analysis Reveals Insights into Resistance of ArabidopsisPlants (Basel, Switzerland) · 2022Article
- LC-MS Based Metabolomics Analysis of Potato (Metabolites · 2022Article
- Synergizing the potential of bacterial genomics and metabolomics to find novel antibiotics.Chemical science · 2021Review
- Article
- Comparative transcriptome profiling of pomegranate genotypes having resistance and susceptible reaction toSaudi journal of biological sciences · 2020Article
- Untargeted metabolomics as a hypothesis-generation tool in plant protection product discovery: Highlighting the potential of trehalose and glycerol metabolism of fungal conidiospores as novel targets.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Metabolomic Fingerprinting of Potato Cultivars Differing in Susceptibility to Spongospora subterranea f. sp. subterranea Root Infection.International journal of molecular sciences · 2020Article
- Advances of Metabolomics in Fungal Pathogen-Plant Interactions.Metabolites · 2019Review
- Review
- Editorial: Metabolomics in Crop Research-Current and Emerging Methodologies.Frontiers in plant science · 2019Article
- Article
- An integrated RNAseq-BMC plant biology · 2017Article
- Alterations in rice chloroplast integrity, photosynthesis and metabolome associated with pathogenesis of Rhizoctonia solani.Scientific reports · 2017Article
- Profiling of Altered Metabolomic States inFrontiers in plant science · 2016Article
- Suppression subtractive hybridization and comparative expression of a pore-forming toxin and glycosyl hydrolase genes in Rhizoctonia solani during potato sprout infection.Molecular genetics and genomics : MGG · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complexity of plant-pathogen interactions makes their dissection a challenging task for metabolomics studies. Here we are reporting on an integrated metabolomics networking approach combining gas chromatography/mass spectrometry (GC/MS) with Fourier transform ion cyclotron resonance/mass spectrometry (FT-ICR/MS) and bioinformatics analyses for the study of interactions in the potato sprout-Rhizoctonia solani pathosystem and the fluctuations in the global metabolome of sprouts. The developed bioanalytical and bioinformatics protocols provided a snapshot of the sprout's global metabolic network and its perturbations as a result of pathogen invasion. Mevalonic acid and deoxy-xylulose pathways were substantially up-regulated leading to the biosynthesis of sesquiterpene alkaloids such as the phytoalexins phytuberin, rishitin, and solavetivone, and steroidal alkaloids having solasodine and solanidine as their common aglycons. Additionally, the perturbation of the sprout's metabolism was depicted in fluctuations of the content of their amino acids pool and that of carboxylic and fatty acids. Components of the systemic acquired resistance (SAR) and hypersensitive reaction (HR) such as azelaic and oxalic acids were detected in increased levels in infected sprouts and strategies of the pathogen to overcome plant defense were proposed. Our metabolic approach has not only greatly expanded the multitude of metabolites previously reported in potato in response to pathogen invasion, but also enabled the identification of bioactive plant-derived metabolites providing valuable information that could be exploited in biotechnology, biomarker-assisted plant breeding, and crop protection for the development of new crop protection agents.
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