Trial reportPloS one2012
The influence of serotonin on fear learning.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans.Molecular psychiatry · 2021Trial
- Effect of Tryptophan Depletion on Conditioned Threat Memory Expression: Role of Intolerance of Uncertainty.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Trial
- Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality.Translational psychiatry · 2021Trial
- Cortico-limbic connectivity in MAOA-L carriers is vulnerable to acute tryptophan depletion.Human brain mapping · 2017Trial
- Serotonin and dopamine differentially affect appetitive and aversive general Pavlovian-to-instrumental transfer.Psychopharmacology · 2015Trial
- Trial
- Monoaminergic Modulation of Learning and Cognitive Function in the Prefrontal Cortex.Brain sciences · 2024Review
- Serotonin and emotion regulation: the impact of tryptophan depletion on emotional experience, neural and autonomic activity.Cognitive, affective & behavioral neuroscience · 2023Article
- The Role of Serotonin in Fear Learning and Memory: A Systematic Review of Human Studies.Brain sciences · 2023Review
- Increased dietary 5-hydroxytryptophan reduces fearfulness in red junglefowl hens (Frontiers in physiology · 2023Article
- Article
- Acquisition learning is stronger for aversive than appetitive events.Communications biology · 2022Article
- The role of serotonin in personality inference: tryptophan depletion impairs the identification of neuroticism in the face.Psychopharmacology · 2017Article
- Neuroimaging of Fear-Associated Learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Serotonin, Amygdala and Fear: Assembling the Puzzle.Frontiers in neural circuits · 2016Review
- Mild Traumatic Brain Injury with Social Defeat Stress Alters Anxiety, Contextual Fear Extinction, and Limbic Monoamines in Adult Rats.Frontiers in behavioral neuroscience · 2016Article
- Representation of aversive prediction errors in the human periaqueductal gray.Nature neuroscience · 2014Article
- Altered functional activations of prefrontal brain areas during emotional processing of fear in Inuit adolescents exposed to environmental contaminants.Neurotoxicology and teratologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Learning of associations between aversive stimuli and predictive cues is the basis of Pavlovian fear conditioning and is driven by a mismatch between expectation and outcome. To investigate whether serotonin modulates the formation of such aversive cue-outcome associations, we used functional magnetic resonance imaging (fMRI) and dietary tryptophan depletion to reduce brain serotonin (5-HT) levels in healthy human subjects. In a Pavlovian fear conditioning paradigm, 5-HT depleted subjects compared to a non-depleted control group exhibited attenuated autonomic responses to cues indicating the upcoming of an aversive event. These results were closely paralleled by reduced aversive learning signals in the amygdala and the orbitofrontal cortex, two prominent structures of the neural fear circuit. In agreement with current theories of serotonin as a motivational opponent system to dopamine in fear learning, our data provide first empirical evidence for a role of serotonin in representing formally derived learning signals for aversive events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.