ArticlePloS one2012
Metagenomic annotation networks: construction and applications.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The evolutionary signal in metagenome phyletic profiles predicts many gene functions.Microbiome · 2018Article
- An analysis of the validity and utility of the proximon proposition.Functional & integrative genomics · 2016Article
- Molecular Detection and Environment-Specific Diversity of Glycosyl Hydrolase Family 1 β-Glucosidase in Different Habitats.Frontiers in microbiology · 2016Article
- MetaProx: the database of metagenomic proximons.Database : the journal of biological databases and curation · 2014Article
- Inference of phenotype-defining functional modules of protein families for microbial plant biomass degraders.Biotechnology for biofuels · 2014Article
- Metagenomic guilt by association: an operonic perspective.PloS one · 2013Article
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Authors and funding
2 authors.
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Abstract
The derivation and comparison of biological interaction networks are vital for understanding the functional capacity and hierarchical organization of integrated microbial communities. In the current work we present metagenomic annotation networks as a novel taxonomy-free approach for understanding the functional architecture of metagenomes. Specifically, metagenomic operon predictions are exploited to derive functional interactions that are translated and categorized according to their associated functional annotations. The result is a collection of discrete networks of weighted annotation linkages. These networks are subsequently examined for the occurrence of annotation modules that portray the functional and organizational characteristics of various microbial communities. A variety of network perspectives and annotation categories are applied to recover a diverse range of modules with different degrees of annotative cohesiveness. Applications to biocatalyst discovery and human health issues are discussed, as well as the limitations of the current implementation.
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