ArticlePloS one2012
Genomic aberrations in an African American colorectal cancer cohort reveals a MSI-specific profile and chromosome X amplification in male patients.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- A Multi-Omics Overview of Colorectal Cancer to Address Mechanisms of Disease, Metastasis, Patient Disparities and Outcomes.Cancers · 2023Review
- Calling Attention to the Role of Race-Driven Societal Determinants of Health on Aggressive Tumor Biology: A Focus on Black Americans.JCO oncology practice · 2022Article
- The lncRNA XIST promotes colorectal cancer cell growth through regulating the miR-497-5p/FOXK1 axis.Cancer cell international · 2020Article
- Higher prevalence of homologous recombination deficiency in tumors from African Americans versus European Americans.Nature cancer · 2020Article
- Lung cancer early detection and health disparities: the intersection of epigenetics and ethnicity.Journal of thoracic disease · 2018Review
- Colorectal Cancer Disparity in African Americans: Risk Factors and Carcinogenic Mechanisms.The American journal of pathology · 2018Review
- Article
- Gender-related prognostic value and genomic pattern of intra-tumor heterogeneity in colorectal cancer.Carcinogenesis · 2017Article
- Long non-coding RNAs in Colorectal Cancer: Progression and Future Directions.Journal of Cancer · 2017Article
- Molecular Biomarkers of Colorectal Cancer and Cancer Disparities: Current Status and Perspective.Current colorectal cancer reports · 2016Article
- Unexpected frequency of genomic alterations in histologically normal colonic tissue from colon cancer patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Genomics of Colorectal Cancer in African Americans.Next generation, sequencing & applications · 2016Article
- Increased MACC1 levels in tissues and blood identify colon adenoma patients at high risk.Journal of translational medicine · 2016Article
- A Systems Biology Interpretation of Array Comparative Genomic Hybridization (aCGH) Data through Phylogenetics.Omics : a journal of integrative biology · 2016Article
- Predicting lncRNA-disease associations and constructing lncRNA functional similarity network based on the information of miRNA.Scientific reports · 2015Article
- Computational Tools for Parsimony Phylogenetic Analysis of Omics Data.Omics : a journal of integrative biology · 2015Article
- ENVE: a novel computational framework characterizes copy-number mutational landscapes in colorectal cancers from African American patients.Genome medicine · 2015Article
- Identification of novel mutations by exome sequencing in African American colorectal cancer patients.Cancer · 2015Article
- Gender-associated genomic differences in colorectal cancer: clinical insight from feminization of male cancer cells.International journal of molecular sciences · 2014Article
- DNA methylome profiling identifies novel methylated genes in African American patients with colorectal neoplasia.Epigenetics · 2014Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveDNA aberrations that cause colorectal cancer (CRC) occur in multiple steps that involve microsatellite instability (MSI) and chromosomal instability (CIN). Herein, we studied CRCs from AA patients for their CIN and MSI status. EXPERIMENTAL
designArray CGH was performed on 30 AA colon tumors. The MSI status was established. The CGH data from AA were compared to published lists of 41 TSG and oncogenes in Caucasians and 68 cancer genes, proposed via systematic sequencing for somatic mutations in colon and breast tumors. The patient-by-patient CGH profiles were organized into a maximum parsimony cladogram to give insights into the tumors' aberrations lineage.
resultsThe CGH analysis revealed that CIN was independent of age, gender, stage or location. However, both the number and nature of aberrations seem to depend on the MSI status. MSI-H tumors clustered together in the cladogram. The chromosomes with the highest rates of CGH aberrations were 3, 5, 7, 8, 20 and X. Chromosome X was primarily amplified in male patients. A comparison with Caucasians revealed an overall similar aberration profile with few exceptions for the following genes; THRB, RAF1, LPL, DCC, XIST, PCNT, STS and genes on the 20q12-q13 cytoband. Among the 68 CAN genes, all showed some level of alteration in our cohort.
conclusionChromosome X amplification in male patients with CRC merits follow-up. The observed CIN may play a distinctive role in CRC in AAs. The clustering of MSI-H tumors in global CGH data analysis suggests that chromosomal aberrations are not random.
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