Evidence map›Paper›PMID 22879095›Full record

ReviewStroke2012

Plasminogen activator inhibitor-1 and thrombotic cerebrovascular diseases.

Anna Tjärnlund-Wolf, Helen Brogren, Eng H Lo, Xiaoying Wang

Abstract readReview
In one paragraph

Review in Stroke, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Intravenous miR-30c therapy confers dual neurovascular protection and improves long-term recovery after ischemic stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  11. Article
  12. Review
  13. Reversing PAI-1 deficiency in blood using mRNA lipid nanoparticles.Molecular therapy. Methods & clinical development · 2025
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anna Tjärnlund-WolfNeuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, 149 13 Street, Room 2411A, Charlestown, MA 02129, USA.
Helen Brogren
Eng H Lo
Xiaoying Wang

Funding

Targeting ROCK for Neurogliovascular Plasticity & Remodeling After StrokeP01NS055104 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LO, ENG H. · 2007 to 2018
$13.3M
Biphasic mechanisms of injury and repair in stroke therapyR37NS037074 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LO, ENG H. · 2008 to 2015
$3.2M
Astrocyte-endothelial crosstalk after cerebral ischemia and hemorrhageR01NS076694 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LO, ENG H. · 2011 to 2015
$1.9M
Recombinant annexin A2 plus tPA for combination stroke therapyR01NS065998 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WANG, XIAOYING · 2010 to 2014
$1.9M
Comparative transcriptome of brain blood vessels: age, hypertension and diabetesRC2NS069335 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LO, ENG H. · 2009 to 2010
$1.3M
NINDS NIH HHS P01 NS055104NINDS NIH HHS R01 NS065998NINDS NIH HHS R01-NS065998NINDS NIH HHS R01 NS076694NINDS NIH HHS R37 NS037074NINDS NIH HHS R37-NS37074NINDS NIH HHS RC2 NS069335
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cerebrovascular DisordersDisease ProgressionHumansIntracranial ThrombosisPlasminogen Activator Inhibitor 1Risk FactorsStrokePlasminogen Activator Inhibitor 1

Identifiers

PMID22879095
PMCPMC3712849

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.