ArticleJournal of computational neuroscience2013
Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron.
Article in Journal of computational neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 35 citations in OpenAlex.
- A biophysical minimal model to investigate age-related changes in CA1 pyramidal cell electrical activity.PloS one · 2024Article
- Biological complexity facilitates tuning of the neuronal parameter space.PLoS computational biology · 2023Article
- A thermodynamic description for physiological transmembrane transport.F1000Research · 2018Article
- CA1 pyramidal cells have diverse biophysical properties, affected by development, experience, and aging.PeerJ · 2017Article
- Neuronal Network Models for Sensory Discrimination.Conference record. Asilomar Conference on Signals, Systems & Computers · 2016Article
- Distal spike initiation zone location estimation by morphological simulation of ionic current filtering demonstrated in a novel model of an identified Drosophila motoneuron.PLoS computational biology · 2015Article
- Modeling the Influence of Ion Channels on Neuron Dynamics in Drosophila.Frontiers in computational neuroscience · 2015Article
- Mathematical analysis of depolarization block mediated by slow inactivation of fast sodium channels in midbrain dopamine neurons.Journal of neurophysiology · 2014Article
- Correlations in ion channel expression emerge from homeostatic tuning rules.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Distinctions among electroconvulsion- and proconvulsant-induced seizure discharges and native motor patterns during flight and grooming: quantitative spike pattern analysis inJournal of neurogeneticsArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Neurons show diverse firing patterns. Even neurons belonging to a single chemical or morphological class, or the same identified neuron, can display different types of electrical activity. For example, motor neuron MN5, which innervates a flight muscle of adult Drosophila, can show distinct firing patterns under the same recording conditions. We developed a two-dimensional biophysical model and show that a core complement of just two voltage-gated channels is sufficient to generate firing pattern diversity. We propose Shab and DmNa v to be two candidate genes that could encode these core currents, and find that changes in Shab channel expression in the model can reproduce activity resembling the main firing patterns observed in MN5 recordings. We use bifurcation analysis to describe the different transitions between rest and spiking states that result from variations in Shab channel expression, exposing a connection between ion channel expression, bifurcation structure, and firing patterns in models of membrane potential dynamics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.