ReviewJournal of perinatology : official journal of the California Perinatal Association2013
Ototoxicity in preterm infants: effects of genetics, aminoglycosides, and loud environmental noise.
Review in Journal of perinatology : official journal of the California Perinatal Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 109 citations in OpenAlex.
- Choice, confounding, and consequence: twenty years of empiric antibiotics for neonatal early-onset sepsis.Pediatric research · 2026Article
- From clusters to clinical rules: unsupervised machine learning identifies four newborn hearing phenotypes with bedside risk stratification.BMC pediatrics · 2026Article
- Subtype-Specific Vulnerability of Spiral Ganglion Neurons in Sensorineural Hearing Loss Across the Lifespan.Brain sciences · 2026Review
- Mechanisms, prevention, and management of aminoglycoside-induced hearing loss in neonates and children: a translational review.Frontiers in pharmacology · 2026Review
- Perinatal risk factors in ex-preterm and/or low birthweight Colombian young adults: a retrospective cohort study on auditory and visual impairments.Lancet regional health. Americas · 2024Article
- Ototoxic and nephrotoxic drugs in neonatal intensive care units: results of a Spanish and Italian survey.European journal of pediatrics · 2024Article
- Home Musical Activities Boost Premature Infants' Language Development.Children (Basel, Switzerland) · 2024Article
- Association between neurodevelopmental outcomes and concomitant presence of NEC and IVH in extremely low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Hearing Loss and Risk Factors in Very Low Birth Weight Infants.Journal of clinical medicine · 2023Article
- Complications associated with incorrect use of nasal CPAP.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Overcoming barriers: a review on innovations in drug delivery to the middle and inner ear.Frontiers in pharmacology · 2023Review
- The impact of premature extrauterine exposure on infants' stimulus-evoked brain activity across multiple sensory systems.NeuroImage. Clinical · 2022Article
- Newborn Incubators Do Not Protect from High Noise Levels in the Neonatal Intensive Care Unit and Are Relevant Noise Sources by Themselves.Children (Basel, Switzerland) · 2021Article
- The Soundscape of Neonatal Intensive Care: A Mixed-Methods Study of the Parents' Experience.Children (Basel, Switzerland) · 2021Article
- Level and Noise Sources in the Neonatal Intensive Care Unit of a Reference Hospital.Investigacion y educacion en enfermeria · 2020Article
- The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications.Seminars in fetal & neonatal medicine · 2020Article
- Early environment and long-term outcomes of preterm infants.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- A proposal for comprehensive newborn hearing screening to improve identification of deaf and hard-of-hearing children.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Open chromatin dynamics in prosensory cells of the embryonic mouse cochlea.Scientific reports · 2019Article
- Ototoxicity: Visualized in Concept Maps.Seminars in hearing · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Majority of hearing-loss cases with extremely preterm infants have no known etiology. There is a growing concern that the administration of aminoglycoside treatment in the noisy environment of the Neonatal Intensive Care Unit (NICU) may lead to hair-cell damage and subsequent auditory impairments. In addition, several mitochondrial DNA mutations are known to have been associated with aminoglycoside-induced hearing loss. This review provides a systematic analysis of the research in this area and elucidates the multifactorial mechanisms behind how mitochondrial DNA mutations, aminoglycosides and loud noise can potentiate ototoxicity in extremely preterm neonates. Recommended steps to minimize the risk of ototoxicity and improve clinical care for NICU infants are discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.