Evidence map›Paper›PMID 22878430›Full record

Trial reportJournal of neurology2012

Genetic risk factors in Parkinson's disease: single gene effects and interactions of genotypes.

Anna Göbel, Eric A Macklin, Susen Winkler, Rebecca A Betensky, Christine Klein, Katja Lohmann, David K Simon

Abstract readClinical TrialLetter
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Association between ubiquitin carboxy-terminal hydrolase-L1 S18Y variant and risk of Parkinson's disease: the impact of ethnicity and onset age.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015
    Pooled it
  2. Lack of association between UCHL1 S18Y gene polymorphism and Parkinson's disease in the Asian population: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014
    Pooled it
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna Göbel
Eric A Macklin
Susen Winkler
Rebecca A Betensky
Christine Klein
Katja Lohmann
David K Simon

Funding

THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GOMEZ-ISLA, TERESA · 1985 to 2018
$42.1M
Training in Neurostatistics and NeuroepidemiologyT32NS048005 · NINDS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ONNELA, JUKKA-PEKKA · 2004 to 2018
$3.2M
Statistical Methods for Analysis of Failure Time DataR01CA075971 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI BETENSKY, REBECCA A. · 2003 to 2009
$1.3M
NCI NIH HHS R01 CA075971NIA NIH HHS P50 AG005134NINDS NIH HHS T32 NS048005
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

GenotypeArylamine N-AcetyltransferaseEpistasis, GeneticGenetic Diseases, InbornGenetic Predisposition to DiseaseHumansParkinson DiseasePolymorphism, GeneticRisk FactorsUbiquitin ThiolesteraseArylamine N-AcetyltransferaseNAT2 protein, humanUbiquitin ThiolesteraseUCHL1 protein, human

Identifiers

PMID22878430
PMCPMC3670989

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.