Trial reportNeurobiology of aging2013
Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals.
Trial report in Neurobiology of aging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cross-sectional associations of amyloid burden with semantic cognition in older adults without dementia: A systematic review and meta-analysis.Mechanisms of ageing and development · 2020Pooled it
- Detectable Neuropsychological Differences in Early Preclinical Alzheimer's Disease: A Meta-Analysis.Neuropsychology review · 2017Pooled it
- Validation of longitudinal change in proper name recall with pTau217 as a marker of early cognitive decline in cognitively unimpaired adults at risk for Alzheimer's disease dementia.Journal of Alzheimer's disease : JAD · 2026Article
- Brain maintenance biomarkers from structural and functional interactions in aging and neurodegeneration.Nature communications · 2026Article
- Development and Implementation of a Radiation Safety Screening Protocol for a Clinical Study Using Amyloid Positron Emission Tomography Imaging.Ochsner journal · 2026Article
- Identification of Hasegawa Dementia Scale-Revised Cutoff Scores Associated With Mini-Mental State Examination Thresholds for Anti-Amyloid β Therapies in Patients With Amnesia.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2025Article
- A brief history of Aβ imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Sex differences in story recall decline in preclinical Alzheimer's disease.Brain communications · 2025Article
- Seeing beyond the symptoms: biomarkers and brain regions linked to cognitive decline in Alzheimer's disease.Frontiers in aging neuroscience · 2024Article
- Multi-domain cognition dysfunction accompanies frontoparietal and temporal amyloid accumulation in the elderly.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Signaling interactions among neurons impact cell fitness and death in Alzheimer's disease.Neural regeneration research · 2023Article
- A Pilot Study on Cerebral Blood Flow and Mini-Mental State Examination to Predict Amyloid Deposition in Preclinical Alzheimer's Disease.Psychiatry and clinical psychopharmacology · 2023Article
- PET molecular imaging for pathophysiological visualization in Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2023Review
- Association of β-Amyloid Accumulation With Executive Function in Adults With Unimpaired Cognition.Neurology · 2022Article
- Apolipoprotein E ɛ4-related effects on cognition are limited to the Alzheimer's disease spectrum.GeroScience · 2022Article
- Unsupervised mobile app-based cognitive testing in a population-based study of older adults born 1944.Frontiers in digital health · 2022Article
- Amyloid-Beta Influences MemoryFrontiers in aging neuroscience · 2021Article
- Association Between Visual Memory andJournal of the International Neuropsychological Society : JINS · 2021Article
- Current advances in digital cognitive assessment for preclinical Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Review
- Predicting future rates of tau accumulation on PET.Brain : a journal of neurology · 2020Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
The objective of this study was to evaluate the relationship of amyloid burden, as assessed by florbetapir F 18 ((18)F-AV-45) amyloid positron emission tomography, and cognition in healthy older control (HC) subjects. Seventy-eight HC subjects were assessed with a brief cognitive test battery and positron emission tomography (PET) imaging with (18)F-AV-45. A standard uptake value ratio was computed for mean data from 6 cortical regions using a whole cerebellum reference region. Scans were also visually rated as amyloid positive or amyloid negative by 3 readers. Higher standard uptake value ratio correlated with lower immediate memory (r = -0.33; p = 0.003) and delayed recall scores (r = -0.25; p = 0.027). Performance on immediate recall was also lower in the visually rated amyloid positive compared with amyloid negative HC (p = 0.04), with a similar trend observed in delayed recall (p = 0.06). These findings support the hypothesis that higher amyloid burden is associated with lower memory performance among clinically normal older subjects. Longitudinal follow-up is ongoing to determine whether (18)F-AV-45 may also predict subsequent cognitive decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.