ArticleDevelopmental biology2012
A cis-regulatory module upstream of deltaC regulated by Ntla and Tbx16 drives expression in the tailbud, presomitic mesoderm and somites.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Tbx16 and mesogenin 1 promote presomitic mesoderm differentiation by repressing the mesodermal progenitor cell state.PLoS genetics · 2026Article
- Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops.Frontiers in cell and developmental biology · 2022Article
- Identification of in vivo Hox13-binding sites reveals an essential locus controlling zebrafish brachyury expression.Development (Cambridge, England) · 2021Article
- Fgf-driven Tbx protein activities directly induceDevelopment (Cambridge, England) · 2020Article
- In Vivo Regulation of the Zebrafish Endoderm Progenitor Niche by T-Box Transcription Factors.Cell reports · 2017Article
- Tales of Tails (and Trunks): Forming the Posterior Body in Vertebrate Embryos.Current topics in developmental biology · 2016Review
- Brachyury, Foxa2 and the cis-Regulatory Origins of the Notochord.PLoS genetics · 2015Article
- Tbx16 and Msgn1 are required to establish directional cell migration of zebrafish mesodermal progenitors.Developmental biology · 2015Article
- The Drosophila T-box transcription factor Midline functions within the Notch-Delta signaling pathway to specify sensory organ precursor cell fates and regulates cell survival within the eye imaginal disc.Mechanisms of developmentArticle
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Authors and funding
3 authors.
Funding
Abstract
Somites form by an iterative process from unsegmented, presomitic mesoderm (PSM). Notch pathway components, such as deltaC (dlc) have been shown to play a role in this process, while the T-box transcription factors Ntla and Tbx16 regulate somite formation upstream of this by controlling supply and movement of cells into the PSM during gastrulation and tailbud outgrowth. In this work, we report that Ntla and Tbx16 play a more explicit role in segmentation by directly regulating dlc expression. In addition we describe a cis-regulatory module (CRM) upstream of dlc that drives expression of a reporter in the tailbud, PSM and somites during somitogenesis. This CRM is bound by both Ntla and Tbx16 at a cluster of T-box binding sites, which are required in combination for activation of the CRM.
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Registered trials
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