Evidence map›Paper›PMID 22877814›Full record

Trial reportAmerican heart journal2012

Randomized trial of lottery-based incentives to improve warfarin adherence.

Stephen E Kimmel, Andrea B Troxel, George Loewenstein, Colleen M Brensinger, Jane Jaskowiak, Jalpa A Doshi, Mitchell Laskin, Kevin Volpp

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American heart journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 65 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03022266 nacompletednot on this mapstarted 2017, after this paper: background citation

A Behavioral Economics-Based Telehealth Intervention to Improve Post-MI Medication Adherence

TypeinterventionalSponsorWellth Inc.Ran2017 to 2018Enrolled130ConditionsMyocardial Infarction, Acute, Myocardial InfarctionArmsFinancial Incentive and Mobile Phone App
NCT03090646 naterminatednot on this mapstarted 2017, after this paper: background citation

Use of Financial Incentives to Increase Live Kidney Donor Follow-up Compliance

TypeinterventionalSponsorJohns Hopkins UniversityRan2017 to 2024Enrolled140ConditionsLiving Donors, Nephrectomy, KidneyArmsFinancial Incentive
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Anticipated regret and health behavior: A meta-analysis.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2016
    Pooled it
  4. Interventions for enhancing medication adherence.The Cochrane database of systematic reviews · 2014
    Pooled it
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  13. Partners and Alerts in Medication Adherence: A Randomized Clinical Trial.Journal of general internal medicine · 2018 · on this map
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  16. Commitment Lotteries Promote Physical Activity Among Overweight Adults-A Cluster Randomized Trial.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stephen E KimmelDepartment of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6021, USA. stevek@mail.med.upenn.edu
Andrea B Troxel
George Loewenstein
Colleen M Brensinger
Jane Jaskowiak
Jalpa A Doshi
Mitchell Laskin
Kevin Volpp

Funding

A randomized trial of interventions to improve warfarin adherenceR01HL090929 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KIMMEL, STEPHEN E., VOLPP, KEVIN G · 2008 to 2011
$3.1M
NHLBI NIH HHS R01 HL090929
6 · The paper itself

Abstract

backgroundPoor adherence to medications is a major cause of morbidity and inadequate drug effectiveness. Efforts to improve adherence have typically been either ineffective or too complex to implement in clinical practice. Lottery-based incentive interventions could be a scalable approach to improving adherence.

methodsThis was a randomized, controlled clinical trial of a daily lottery-based incentive in patients on warfarin stratified by baseline international normalized ratio (INR). The trial randomized 100 patients to either a lottery-based incentive or no lottery intervention. Main outcome was out-of-range INRs.

resultsOver 6 months, the overall percentage of out-of-range INRs did not differ between the 2 arms (mean 23.0% in lottery arm and 25.9% in control arm, adjusted odds ratio [OR] 0.93, 95% CI 0.62-1.41). However, among the a priori subgroup with a baseline INR below therapeutic range, there was a significant reduction in out-of-range INR in the lottery arm versus the control arm (adjusted OR 0.39, 95% CI 0.25-0.62), whereas there was no such effect among those with therapeutic INRs at baseline (adjusted OR 1.26, 95% CI, 0.76-2.09, P value for interaction = .0016). Among those with low INR at baseline, there was a nonsignificant 49% reduction in the odds of nonadherence with the intervention (OR 0.51, 95% CI 0.23-1.14).

conclusionsAlthough a lottery-based intervention was not associated with a significant improvement in anticoagulation control among all study participants, it improved control among an a priori group of patients at higher risk for poor adherence.

Indexed as

Medication AdherenceMotivationAgedAnticoagulantsCardiovascular DiseasesFemaleHemorrhageHumansMaleMiddle AgedThromboembolismWarfarinAnticoagulantsWarfarin

Identifiers

PMID22877814
PMCPMC4738867

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.