ReviewProgress in brain research2012
The impact of the circadian timing system on cardiovascular and metabolic function.
Review in Progress in brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Sleep, Hypertension, and Cardiovascular Risk in Children and Adolescents.Current hypertension reports · 2018Pooled it
- Dietary Modification with Food Order and Divided Carbohydrate Intake Improves Glycemic Excursions in Healthy Young Women.Nutrients · 2025Trial
- Effectiveness of Early Versus Late Time-Restricted Eating Combined with Physical Activity in Overweight or Obese Women.Nutrients · 2025Trial
- Effect of changes in children's bedtime and sleep period on targeted eating behaviors and timing of caloric intake.Eating behaviors · 2022Trial
- Strengthening sleep-autonomic interaction via acoustic enhancement of slow oscillations.Sleep · 2019Trial
- Night shift work exposure profile and obesity: Baseline results from a Chinese night shift worker cohort.PloS one · 2018Trial
- Circadian misalignment increases cardiovascular disease risk factors in humans.Proceedings of the National Academy of Sciences of the United States of America · 2016Trial
- Effects of the Internal Circadian System and Circadian Misalignment on Glucose Tolerance in Chronic Shift Workers.The Journal of clinical endocrinology and metabolism · 2016Trial
- Clock Genes Explain a Large Proportion of Phenotypic Variance in Systolic Blood Pressure and This Control Is Not Modified by Environmental Temperature.American journal of hypertension · 2016Trial
- The Human Circadian System Has a Dominating Role in Causing the Morning/Evening Difference in Diet-Induced Thermogenesis.Obesity (Silver Spring, Md.) · 2015Trial
- Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans.Proceedings of the National Academy of Sciences of the United States of America · 2015Trial
- Circadian disruption exacerbates alcohol-induced cardiac injury through impaired cellular quality control and increased cardiomyocyte death.Molecular and cellular biochemistry · 2026Article
- Six weeks stretching of lower limbs lowers blood pressure in hypertensive individuals.European journal of applied physiology · 2026Article
- Interpreting Continuous Glucose Monitoring Through Metabolic Physiology: A Framework for Precision Nutrition in Type 2 Diabetes.Nutrients · 2026Review
- Unlocking the potential of circadian biology for cardiovascular health.Physiological reviews · 2026Review
- The effect of timing of physical exercise on glycemia: a systematic review and meta-analysis of human intervention studies.Journal of diabetes and metabolic disorders · 2026Review
- Translational applications of circadian research: connecting chronobiology to medicine.Npj biological timing and sleep · 2026Review
- Circadian troponin dynamics reveal sex-specific signals for acute coronary syndrome evaluation.Internal and emergency medicine · 2026Article
- Beetroot Juice Enhances Nitrate Metabolism and Endothelial Function but Not Cardiovascular or Strength Performance in Bodybuilders with a History of Anabolic-Androgenic Steroid Abuse: A Crossover Trial.Antioxidants (Basel, Switzerland) · 2026Article
- Circadian preference and quality of life in adults with autism spectrum disorder: a Brazilian cross-sectional self-reported survey.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Epidemiological studies show that adverse cardiovascular events peak in the morning (i.e., between 6 AM and noon) and that shift work is associated with cardiovascular disease, obesity, and diabetes. The endogenous circadian timing system modulates certain cardiovascular risk markers to be highest (e.g., cortisol, nonlinear dynamic heart rate control, and platelet activation) or to respond most unfavorably to stressors such as exercise (e.g., epinephrine, norepinephrine, and vagal cardiac modulation) at an internal body time corresponding to the time of day when adverse cardiovascular events most likely occur. This indicates that the circadian timing system and its interaction with external cardiovascular stressors (e.g., physical activity) could contribute to the morning peak in adverse cardiovascular events. Moreover, circadian misalignment and simulated night work have adverse effects on cardiovascular and metabolic function. This suggests that misalignment between the behavioral cycle and the circadian timing system in shift workers contributes to that population's increased risk for cardiometabolic disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.