Evidence map›Paper›PMID 22877650›Full record

ReviewLife sciences2013

Drosophila TRP channels and animal behavior.

Melissa A Fowler, Craig Montell

Abstract readReview
In one paragraph

Review in Life sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 204 citations in OpenAlex.

  1. Article
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  4. Review
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  18. iScience · 2024
    Article
  19. Article
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Melissa A FowlerDepartment of Biological Chemistry, Center for Sensory Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Craig Montell
Johns Hopkins Medicine · US

Funding

Unconventional roles for opsinsR01EY008117 · NEI · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI MONTELL, CRAIG · 1989 to 2022
$8.2M
TRP CHANNEL SIGNALING COMPLEX AND ITS ROLE IN VISIONR01EY010852 · NEI · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI MONTELL, CRAIG · 1995 to 2021
$7.9M
Molecular Genetics of Taste TransductionR01DC007864 · NIDCD · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI CRAIG MONTELL · 2006 to 2026
$7.5M
TRPA1: a polymodal sensor for aversive stimuliR01GM085335 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI MONTELL, CRAIG · 2008 to 2015
$2.8M
NEI NIH HHS R01 EY008117NEI NIH HHS R01 EY010852NIDCD NIH HHS R01 DC007864NIGMS NIH HHS R01 GM085335
6 · The paper itself

Abstract

Multiple classes of cell surface receptors and ion channels participate in the detection of changes in environmental stimuli, and thereby influence animal behavior. Among the many classes of ion channels, Transient Receptor Potential (TRP) cation channels are notable in contributing to virtually every sensory modality, and in controlling a daunting array of behaviors. TRP channels appear to be conserved in all metazoan organisms including worms, insects and humans. Flies encode 13 TRPs, most of which are expressed and function in sensory neurons, and impact behaviors ranging from phototaxis to thermotaxis, gravitaxis, the avoidance of noxious tastants and smells and proprioception. Multiple diseases result from defects in TRPs, and flies provide an excellent animal model for dissecting the mechanisms underlying "TRPopathies." Drosophila TRPs also function in the sensation of botanically derived insect repellents, and related TRPs in insect pests are potential targets for the development of improved repellents to combat insect-borne diseases.

Indexed as

AnimalsBehavior, AnimalDrosophilaHot TemperatureLightMechanoreceptorsProprioceptionSensationTransient Receptor Potential ChannelsTransient Receptor Potential Channels

Identifiers

PMID22877650
PMCPMC3524398
OpenAlexW2065275899

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.