ArticleScientific reports2012
Mechanisms for redox actions of nicotine and glutathione in cell culture, relevant to periodontitis.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Decoding different oxidative stress pathways in periodontitis: a comparative review of mechanisms of traditional tobacco smoke and electronic smoke aerosol.Archives of toxicology · 2025Review
- Androgen receptor signaling-mitochondrial DNA-oxidative phosphorylation: A critical triangle in early prostate cancer.Current urology · 2022Article
- Beneficial Effects of Green Tea EGCG on Skin Wound Healing: A Comprehensive Review.Molecules (Basel, Switzerland) · 2021Review
- Ethanol- and Cigarette Smoke-Related Alternations in Oral Redox Homeostasis.Frontiers in physiology · 2021Review
- Effect of smokeless tobacco use on salivary glutathione levels among chronic periodontitis patients before and after non-surgical periodontal therapy.Tobacco prevention & cessation · 2020Article
- Review
- Influence of Dental Restorations on Oxidative Stress in Gingival Crevicular Fluid.Oxidative medicine and cellular longevity · 2018Article
- The Expression of B7-H3 Molecule in Periodontal Disease.Journal of dentistry (Shiraz, Iran) · 2017Article
- Cytotoxicity and apoptosis induction by e-cigarette fluids in human gingival fibroblasts.Clinical oral investigations · 2016Article
- The antioxidant master glutathione and periodontal health.Dental research journalReview
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oxidative effect of nicotine was investigated using androgen biomarkers of redox status and wound healing in fibroblasts; using the antioxidant glutathione for confirmation of responses. Cultures of human gingival (HGF) and periosteal fibroblasts (HPF) were incubated with substrates 14C-testosterone/14C-4-androstenedione in the presence or absence of serial concentrations of nicotine (N(100-500)), glutathione (G(1-5)) and their combinations, in medium. At 24 h the medium was solvent extracted for metabolites, separated by TLC and quantified using radioisotope scanning. Nicotine caused significant inhibition in yields of the physiologically active metabolite 5α-dihydrotestosterone (DHT) in HGF and HPF, overcome to varying degrees by the anti-oxidant glutathione (n = 6; p<0.01, one way ANOVA); this is suggestive of moderation of an oxidative mechanism induced by nicotine. Down-regulation of 5α-reductase activity by nicotine resulting in reduced yields of DHT was overcome by glutathione. Overcoming oxidative stress in a redox environment is applicable to treatment outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.