ArticlePloS one2012
Specialized motor-driven dusp1 expression in the song systems of multiple lineages of vocal learning birds.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 52 citations in OpenAlex.
- Gene regulatory co-option drives birdsong neural circuit specialization.bioRxiv : the preprint server for biology · 2026Article
- Auditory Representation of Vocal Signals in a Pallial Cortical Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A versatile pipeline to identify convergently lost ancestral conserved fragments associated with convergent evolution of vocal learning.Briefings in bioinformatics · 2024Article
- Article
- Delving into the Genetic Causes of Language Impairment in a Case of Partial Deletion ofMolecular syndromology · 2023Article
- Forebrain nuclei linked to woodpecker territorial drum displays mirror those that enable vocal learning in songbirds.PLoS biology · 2022Article
- HippocampalThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Seasonal regulation of singing-driven gene expression associated with song plasticity in the canary, an open-ended vocal learner.Molecular brain · 2021Article
- Controlling for activity-dependent genes and behavioral states is critical for determining brain relationships within and across species.The Journal of comparative neurology · 2021Article
- Human Genomics and the Biocultural Origin of Music.International journal of molecular sciences · 2021Review
- ZEBrA: Zebra finch Expression Brain Atlas-A resource for comparative molecular neuroanatomy and brain evolution studies.The Journal of comparative neurology · 2020Article
- Inception of memories that guide vocal learning in the songbird.Science (New York, N.Y.) · 2019Article
- Robust Candidates for Language Development and Evolution Are Significantly Dysregulated in the Blood of People With Williams Syndrome.Frontiers in neuroscience · 2019Article
- De novo PacBio long-read and phased avian genome assemblies correct and add to reference genes generated with intermediate and short reads.GigaScience · 2017Article
- Brain evolution by brain pathway duplication.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Convergent differential regulation of SLIT-ROBO axon guidance genes in the brains of vocal learners.The Journal of comparative neurology · 2015Article
- The effect of music performance on the transcriptome of professional musicians.Scientific reports · 2015Article
- Audition-independent vocal crystallization associated with intrinsic developmental gene expression dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Core and Shell Song Systems Unique to the Parrot Brain.PloS one · 2015Article
- Core and region-enriched networks of behaviorally regulated genes and the singing genome.Science (New York, N.Y.) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Mechanisms for the evolution of convergent behavioral traits are largely unknown. Vocal learning is one such trait that evolved multiple times and is necessary in humans for the acquisition of spoken language. Among birds, vocal learning is evolved in songbirds, parrots, and hummingbirds. Each time similar forebrain song nuclei specialized for vocal learning and production have evolved. This finding led to the hypothesis that the behavioral and neuroanatomical convergences for vocal learning could be associated with molecular convergence. We previously found that the neural activity-induced gene dual specificity phosphatase 1 (dusp1) was up-regulated in non-vocal circuits, specifically in sensory-input neurons of the thalamus and telencephalon; however, dusp1 was not up-regulated in higher order sensory neurons or motor circuits. Here we show that song motor nuclei are an exception to this pattern. The song nuclei of species from all known vocal learning avian lineages showed motor-driven up-regulation of dusp1 expression induced by singing. There was no detectable motor-driven dusp1 expression throughout the rest of the forebrain after non-vocal motor performance. This pattern contrasts with expression of the commonly studied activity-induced gene egr1, which shows motor-driven expression in song nuclei induced by singing, but also motor-driven expression in adjacent brain regions after non-vocal motor behaviors. In the vocal non-learning avian species, we found no detectable vocalizing-driven dusp1 expression in the forebrain. These findings suggest that independent evolutions of neural systems for vocal learning were accompanied by selection for specialized motor-driven expression of the dusp1 gene in those circuits. This specialized expression of dusp1 could potentially lead to differential regulation of dusp1-modulated molecular cascades in vocal learning circuits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.