ArticlePloS one2012
Molecular characterization of pathogenic members of the genus Fonsecaea using multilocus analysis.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Predominance of Fonsecaea nubica in Chromoblastomycosis: A Single-Centre Study from Southern India.Mycopathologia · 2026Article
- Development of PCR-Multiplex Assays for Identification of the Herpotrichiellaceae Family and Agents Causing Chromoblastomycosis.Journal of fungi (Basel, Switzerland) · 2024Article
- Identification of Chromoblastomycosis and Phaeohyphomycosis Agents through ITS-RFLP.Journal of fungi (Basel, Switzerland) · 2024Article
- Molecular Diagnosis of Two Major Implantation Mycoses: Chromoblastomycosis and Sporotrichosis.Journal of fungi (Basel, Switzerland) · 2022Review
- Chromoblastomycosis in an Endemic Area of Brazil: A Clinical-Epidemiological Analysis and a Worldwide Haplotype Network.Journal of fungi (Basel, Switzerland) · 2020Article
- New Molecular Markers Distinguishing Fonsecaea Agents of Chromoblastomycosis.Mycopathologia · 2019Article
- Chromoblastomycosis Caused by Fonsecaea nubica: First Report in Northern China and Literature Review.Mycopathologia · 2019Review
- Differential distribution patterns of Fonsecaea agents of chromoblastomycosis, exemplified by the first case due to F. monophora from Argentina.Medical mycology case reports · 2018Article
- Indoor wet cells as a habitat for melanized fungi, opportunistic pathogens on humans and other vertebrates.Scientific reports · 2018Article
- Exploring the genomic diversity of black yeasts and relatives (Studies in mycology · 2017Article
- Chromoblastomycosis.Clinical microbiology reviews · 2017Review
- Molecular Epidemiology of Agents of Human Chromoblastomycosis in Brazil with the Description of Two Novel Species.PLoS neglected tropical diseases · 2016Article
- Cerebral phaeohyphomycosis by Fonsecaea monophora: Report in a patient with AIDS and a ring enhancing lesion.Medical mycology case reports · 2016Article
- Shared Physiological Traits of Exophiala Species in Cold-Blooded Vertebrates, as Opportunistic Black Yeasts.Mycopathologia · 2016Article
- The role of melanin pathways in extremotolerance and virulence of Fonsecaea revealed by de novo assembly transcriptomics using illumina paired-end sequencing.Studies in mycology · 2016Article
- First case of chromoblastomycosis from Bangladesh.Medical mycology case reports · 2015Article
- Fonsecaea pugnacius, a Novel Agent of Disseminated Chromoblastomycosis.Journal of clinical microbiology · 2015Article
- Chromoblastomycosis due to Fonsecaea monophora in a man with nephritic syndrome.Mycopathologia · 2015Article
- Global Spread of Human Chromoblastomycosis Is Driven by Recombinant Cladophialophora carrionii and Predominantly Clonal Fonsecaea Species.PLoS neglected tropical diseases · 2015Article
- Case ofJMM case reports · 2014Article
Corrections and comments
- Erratum issuedNajafzadeh, Mohammed J [corrected to Najafzadeh, Mohammad J]
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Members of the fungal genus Fonsecaea causing human chromoblastomycosis show substantial geographic structuring. Genetic identity of clinical and environmental strains suggests transmission from plant debris, while the evolutionary processes that have led to spatially separated populations have remained unexplained. Sequences of ITS, BT2, ACT1, Cdc42, Lac and HmgA were analyzed, either by direct sequencing or by cloning. Thirty-seven clinical and environmental Fonsecaea strains from Central and South America, Asia, Africa and Europe were sequenced and possible recombination events were calculated. Phylogenetic trees of Cdc42, Lac and HmgA were statistically supported, but ITS, BT2 and ACT1 trees were not. The Standardized Index of Association (I(A) (S)) did not detect recombination (I(A) (S) = 0.4778), neither did the Phi-test for separate genes. In Fonsecaea nubica non-synonymous mutations causing functional changes were observed in Lac gene, even though no selection pressures were detected with the neutrality test (Tajima D test, p>0.05). Genetic differentiation of populations for each gene showed separation of American, African and Asian populations. Strains of clinical vs. environmental origin showed genetic distances that were comparable or lower than found in geographic differentiation. In conclusion, here we demonstrated clonality of sibling species using multilocus data, geographic structuring of populations, and a low functional and structural selective constraint during evolution of the genus Fonsecaea.
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