ArticleFrontiers in integrative neuroscience2012
Hypotheses relating to the function of the claustrum.
Article in Frontiers in integrative neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.
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Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Human lesions and animal studies link the claustrum to perception, salience, sleep and pain.Brain : a journal of neurology · 2022Pooled it
- Brain responses to social punishment: a meta-analysis.Scientific reports · 2019Pooled it
- The primate claustrum as a hub for precision weighting of prediction errors across the cortical hierarchy.PLoS biology · 2026Article
- Similarities of neocortical deep layeriScience · 2025Article
- A Contrast-Agnostic Method for Ultra-High Resolution Claustrum Segmentation.Human brain mapping · 2025Article
- A comprehensive and reliable protocol for manual segmentation of the human claustrum using high-resolution MRI.Brain structure & function · 2025Article
- Single neurons and networks in the mouse claustrum integrate input from widespread cortical sources.eLife · 2025Article
- The Role of the Claustrum in Parkinson's Disease and Vascular Parkinsonism: A Matter of Network?Life (Basel, Switzerland) · 2025Review
- Cocaine self-administration attenuates brain glucose metabolism and functional connectivity in rats.PloS one · 2025Article
- The role of the claustrum in the acquisition, consolidation and reconsolidation of memories in mice.Scientific reports · 2024Article
- Human Claustrum Connections: Robust In Vivo Detection by DWI-Based Tractography in Two Large Samples.Human brain mapping · 2024Article
- Involvement of the claustrum in the cortico-basal ganglia circuitry: connectional study in the non-human primate.Brain structure & function · 2024Article
- Differential distribution of inhibitory neuron types in subregions of claustrum and dorsal endopiriform nucleus of the short-tailed fruit bat.Brain structure & function · 2022Article
- Article
- Functional properties of eyelid conditioned responses and involved brain centers.Frontiers in behavioral neuroscience · 2022Review
- Topologically Organized Networks in the Claustrum Reflect Functional Modularization.Frontiers in neuroanatomy · 2022Article
- Feelings of Knowing - Fundamental Interoceptive Patterns (FoK-FIP): a magnetic monopole-like "pure mental" process fundamental to subjective feelings and self-awareness.Communicative & integrative biology · 2022Article
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- Article
- A unifying theory of physics and biological information through consciousness.Communicative & integrative biology · 2021Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper present a new hypothesis as to the function of the claustrum. Our basic premise is that the claustrum functions as a detector and integrator of synchrony in the axonal trains in its afferent inputs. In the first place an unexpected stimulus sets up a processed signal to the sensory cortex that initiates a focus of synchronized gamma oscillations therein. This focus may then interact with a general alerting signal conveyed from the reticular formation via cholinergic mechanisms, and with other salient activations set up by the stimulus in other sensory pathways that are relayed to the cortex. This activity is relayed from the cortex to the claustrum, which then processes these several inputs by means of multiple competitive intraclaustral synchronized oscillations at different frequencies. Finally it modulates the synchronized outputs that the claustrum distributes to most cortical and many subcortical structures, including the motor cortex. In this way, during multicenter perceptual and cognitive operations, reverberating claustro-cortical loops potentiate weak intracortical synchronizations by means of connected strong intraclaustral synchronizations. These may also occur without a salient stimulus. By this mechanism, the claustrum may play a strong role in the control of interactive processes in different parts of the brain, and in the control of voluntary behavior. These may include the neural correlates of consciousness. We also consider the role of GABAergic mechanisms and deafferentation plasticity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.