ArticlePLoS genetics2012
Population genomics of the facultatively mutualistic bacteria Sinorhizobium meliloti and S. medicae.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Biogeographic and Genomic Signatures of Thermal Adaptation in Facultative Symbionts.Microbial ecology · 2025Article
- Closed genomes of commercial inoculant rhizobia provide a blueprint for management of legume inoculation.Applied and environmental microbiology · 2025Article
- Improved metagenome assemblies through selective enrichment of bacterial genomic DNA from eukaryotic host genomic DNA using ATAC-seq.Frontiers in microbiology · 2024Article
- Review
- Article
- Article
- Scent of a Symbiont: The Personalized Genetic Relationships of Rhizobium-Plant Interaction.International journal of molecular sciences · 2022Review
- Comparative genomics reveals high rates of horizontal transfer and strong purifying selection on rhizobial symbiosis genes.Proceedings. Biological sciences · 2021Article
- Symbiosis genes show a unique pattern of introgression and selection within aMicrobial genomics · 2020Article
- A Select and Resequence Approach Reveals Strain-Specific Effects ofPlant physiology · 2020Article
- Just the Two of Us? A Family of Pseudomonas Megaplasmids Offers a Rare Glimpse into the Evolution of Large Mobile Elements.Genome biology and evolution · 2019Article
- Flowering plant immune repertoires expand under mycorrhizal symbiosis.Plant direct · 2019Article
- Dynamic genomic architecture of mutualistic cooperation in a wild population of Mesorhizobium.The ISME journal · 2019Article
- Genome-Wide Association Analyses in the Model RhizobiummSphere · 2018Article
- Rhizobia: from saprophytes to endosymbionts.Nature reviews. Microbiology · 2018Review
- The complete replicons of 16 Ensifer meliloti strains offer insights into intra- and inter-replicon gene transfer, transposon-associated loci, and repeat elements.Microbial genomics · 2018Article
- Adaptive evolution of rhizobial symbiotic compatibility mediated by co-evolved insertion sequences.The ISME journal · 2018Article
- Contribution of Mobile Group II Introns toFrontiers in microbiology · 2018Review
- Ancestral Genome Estimation Reveals the History of Ecological Diversification in Agrobacterium.Genome biology and evolution · 2017Article
- The Divided Bacterial Genome: Structure, Function, and Evolution.Microbiology and molecular biology reviews : MMBR · 2017Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The symbiosis between rhizobial bacteria and legume plants has served as a model for investigating the genetics of nitrogen fixation and the evolution of facultative mutualism. We used deep sequence coverage (>100×) to characterize genomic diversity at the nucleotide level among 12 Sinorhizobium medicae and 32 S. meliloti strains. Although these species are closely related and share host plants, based on the ratio of shared polymorphisms to fixed differences we found that horizontal gene transfer (HGT) between these species was confined almost exclusively to plasmid genes. Three multi-genic regions that show the strongest evidence of HGT harbor genes directly involved in establishing or maintaining the mutualism with host plants. In both species, nucleotide diversity is 1.5-2.5 times greater on the plasmids than chromosomes. Interestingly, nucleotide diversity in S. meliloti but not S. medicae is highly structured along the chromosome - with mean diversity (θ(π)) on one half of the chromosome five times greater than mean diversity on the other half. Based on the ratio of plasmid to chromosome diversity, this appears to be due to severely reduced diversity on the chromosome half with less diversity, which is consistent with extensive hitchhiking along with a selective sweep. Frequency-spectrum based tests identified 82 genes with a signature of adaptive evolution in one species or another but none of the genes were identified in both species. Based upon available functional information, several genes identified as targets of selection are likely to alter the symbiosis with the host plant, making them attractive targets for further functional characterization.
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