ArticlePLoS genetics2012
Human developmental enhancers conserved between deuterostomes and protostomes.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 67 citations in OpenAlex.
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- Deep conservation of cis-regulatory elements and chromatin organization in echinoderms uncover ancestral regulatory features of animal genomes.Nature ecology & evolution · 2026Article
- Temporospatial hierarchy and allele-specific expression of zygotic genome activation revealed by distant interspecific urochordate hybrids.Nature communications · 2024Article
- Evolution of the Major Components of Innate Immunity in Animals.Journal of molecular evolution · 2024Review
- DNA Conserved in Diverse Animals Since the Precambrian Controls Genes for Embryonic Development.Molecular biology and evolution · 2023Article
- Perfect and imperfect views of ultraconserved sequences.Nature reviews. Genetics · 2022Review
- ATAC-Seq for Assaying Chromatin Accessibility Protocol Using Echinoderm Embryos.Methods in molecular biology (Clifton, N.J.) · 2021Article
- A Comparative Analysis of Super-Enhancers and Broad H3K4me3 Domains in Pig, Human, and Mouse Tissues.Frontiers in genetics · 2021Article
- Ancient Genomic Regulatory Blocks Are a Source for Regulatory Gene Deserts in Vertebrates after Whole-Genome Duplications.Molecular biology and evolution · 2020Article
- Single-Base Resolution Map of Evolutionary Constraints and Annotation of Conserved Elements across Major Grass Genomes.Genome biology and evolution · 2018Article
- Conserved non-coding elements: developmental gene regulation meets genome organization.Nucleic acids research · 2017Review
- Comparative analyses of super-enhancers reveal conserved elements in vertebrate genomes.Genome research · 2017Article
- GC Content Heterogeneity Transition of Conserved Noncoding Sequences Occurred at the Emergence of Vertebrates.Genome biology and evolution · 2016Article
- Conserved Noncoding Elements in the Most Distant Genera of Cephalochordates: The Goldilocks Principle.Genome biology and evolution · 2016Article
- Coding exon-structure aware realigner (CESAR) utilizes genome alignments for accurate comparative gene annotation.Nucleic acids research · 2016Article
- Evolution of Epigenetic Regulation in Vertebrate Genomes.Trends in genetics : TIG · 2016Review
- A new paradigm for animal symmetry.Interface focus · 2015Review
- Evolution of lineage-specific functions in ancient cis-regulatory modules.Open biology · 2015Article
- Analysis of 5' gene regions reveals extraordinary conservation of novel non-coding sequences in a wide range of animals.BMC evolutionary biology · 2015Article
- Phylum-Level Conservation of Regulatory Information in Nematodes despite Extensive Non-coding Sequence Divergence.PLoS genetics · 2015Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The identification of homologies, whether morphological, molecular, or genetic, is fundamental to our understanding of common biological principles. Homologies bridging the great divide between deuterostomes and protostomes have served as the basis for current models of animal evolution and development. It is now appreciated that these two clades share a common developmental toolkit consisting of conserved transcription factors and signaling pathways. These patterning genes sometimes show common expression patterns and genetic interactions, suggesting the existence of similar or even conserved regulatory apparatus. However, previous studies have found no regulatory sequence conserved between deuterostomes and protostomes. Here we describe the first such enhancers, which we call bilaterian conserved regulatory elements (Bicores). Bicores show conservation of sequence and gene synteny. Sequence conservation of Bicores reflects conserved patterns of transcription factor binding sites. We predict that Bicores act as response elements to signaling pathways, and we show that Bicores are developmental enhancers that drive expression of transcriptional repressors in the vertebrate central nervous system. Although the small number of identified Bicores suggests extensive rewiring of cis-regulation between the protostome and deuterostome clades, additional Bicores may be revealed as our understanding of cis-regulatory logic and sample of bilaterian genomes continue to grow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.