ArticlePLoS genetics2012
Inheritance beyond plain heritability: variance-controlling genes in Arabidopsis thaliana.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
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Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it, 152 citations in OpenAlex.
- Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index.PLoS genetics · 2014Pooled it
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- Establishment and maintenance of NRT2.1 inter-individual variability in plants.PLoS genetics · 2025Article
- Mean and variance heterogeneity loci impact kernel compositional traits in maize.The plant genome · 2025Article
- Barriers and carriers for transition metal homeostasis in plants.Plant communications · 2025Review
- Up-regulation of non-photochemical quenching improves water use efficiency and reduces whole-plant water consumption under drought in Nicotiana tabacum.Journal of experimental botany · 2024Article
- Dual-trait genomic analysis in highly stratified Arabidopsis thaliana populations using genome-wide association summary statistics.Heredity · 2024Article
- Detecting genetic effects on phenotype variability to capture gene-by-environment interactions: a systematic method comparison.G3 (Bethesda, Md.) · 2024Review
- LTP2 hypomorphs show genotype-by-environment interaction in early seedling traits in Arabidopsis thaliana.The New phytologist · 2024Article
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- Genetic dissection of maize (Zea maysL.) trace element traits using genome-wide association studies.BMC plant biology · 2023Article
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- Predicting Gene Regulatory Interactions Using Natural Genetic Variation.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Temperature-mediated flower size plasticity in Arabidopsis.iScience · 2022Article
- The selfing syndrome and beyond: diverse evolutionary consequences of mating system transitions in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Evaluation of the phenotypic and genomic background of variability based on litter size of Large White pigs.Genetics, selection, evolution : GSE · 2022Article
- Genome-Wide Association Study Reveals Genomic Regions Associated With Molybdenum Accumulation in Wheat Grains.Frontiers in plant science · 2022Article
- An eco-evo-devo genetic network model of stress response.Horticulture research · 2022Article
- Local auxin biosynthesis acts downstream of brassinosteroids to trigger root foraging for nitrogen.Nature communications · 2021Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phenotypic effect of a gene is normally described by the mean-difference between alternative genotypes. A gene may, however, also influence the phenotype by causing a difference in variance between genotypes. Here, we reanalyze a publicly available Arabidopsis thaliana dataset [1] and show that genetic variance heterogeneity appears to be as common as normal additive effects on a genomewide scale. The study also develops theory to estimate the contributions of variance differences between genotypes to the phenotypic variance, and this is used to show that individual loci can explain more than 20% of the phenotypic variance. Two well-studied systems, cellular control of molybdenum level by the ion-transporter MOT1 and flowering-time regulation by the FRI-FLC expression network, and a novel association for Leaf serration are used to illustrate the contribution of major individual loci, expression pathways, and gene-by-environment interactions to the genetic variance heterogeneity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.