ArticleMolecular vision2012
Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis.
Article in Molecular vision, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Clinical Characteristics of Posner-Schlossman Syndrome Patients in China.BioMed research international · 2023Article
- Article
- Integrated omics analysis of sweat reveals an aberrant amino acid metabolism pathway in Vogt-Koyanagi-Harada disease.Clinical and experimental immunology · 2020Article
- Use of Laplacian Heat Diffusion Algorithm to Infer Novel Genes With Functions Related to Uveitis.Frontiers in genetics · 2018Article
- Lack of association of C3 gene with uveitis: additional insights into the genetic profile of uveitis regarding complement pathway genes.Scientific reports · 2017Article
- Autoimmune uveitis: clinical, pathogenetic, and therapeutic features.Clinical and experimental medicine · 2016Review
- Association of the C2-CFB locus with non-infectious uveitis, specifically predisposed to Vogt-Koyanagi-Harada disease.Immunologic research · 2016Article
- CFI-rs7356506 polymorphisms associated with Vogt-Koyanagi-Harada syndrome.Molecular vision · 2016Article
- Influence of molecular genetics in Vogt-Koyanagi-Harada disease.Journal of ophthalmic inflammation and infection · 2014Review
- Gender differences in vogt-koyanagi-harada disease and sympathetic ophthalmia.Journal of ophthalmology · 2014Review
- Gene expression profile of peripheral blood monocytes: a step towards the molecular diagnosis of celiac disease?PloS one · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the associations of complement factor H (CFH), KIAA1109, and interleukin-27 (IL-27) gene polymorphisms in patients with non-infectious intermediate and posterior uveitis.
methodsThe study cohort consisted of a total of 95 Chinese non-infectious uveitis patients, including 38 patients with intermediate uveitis (IU), 38 patients with Vogt-Koyanagi-Harada disease (VKH), and 19 patients with Behçet's disease and 308 healthy controls. The genotypes of CFH-rs800292, KIAA1109-rs4505848, and IL27-rs4788084 were determined using TaqMan single nucleotide polymorphism genotyping assays.
resultsThe frequency of carriers of G allele for CFH-rs800292 was significantly higher in patients with non-infectious intermediate and posterior uveitis than in controls (GG/AG versus AA; p=0.02). No significant association was found between uveitis and both KIAA1109-rs4505848 and IL27-rs4788084. In stratified analysis by gender, the frequency of carriers with G allele for KIAA1109-rs4505848 was significantly higher in male uveitis patients than in male controls (GG/AG versus AA; p=0.034). There was no significant difference in allelic and genotypic frequencies for CFH-rs800292 and IL27-rs4788084 in either male or female groups. In addition, higher frequency of KIAA1109-rs4505848 G allele was found in Behçet's disease patients compared with controls and IU patients (p=0.01 and p=0.003, respectively).
conclusionsOur results demonstrated that CFH-rs800292 and KIAA1109-rs4505848 are associated with non-infectious intermediate and posterior uveitis. Moreover, gender susceptibility for uveitis might be involved in the KIAA1109 gene and the KIAA1109-rs4505848 polymorphism might be associated with the development of Behçet's disease.
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Identifiers
22876110PMC3413425W1759505502What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.