ArticleWorld journal of gastroenterology2012
Normal carcinoembryonic antigen indicates benefit from perioperative chemotherapy to gastric carcinoma patients.
Article in World journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Combined Use of Tumor Markers in Gastric Cancer: A Novel Method with Promising Prognostic Accuracy and Practicality.Annals of surgical oncology · 2023Article
- Risk model and factors for prediction of response to neoadjuvant chemotherapy in patients with advanced gastric cancer-a two-center cohort study.BMC cancer · 2023Article
- Carbon Material Based Electrochemical Immunosensor for Gastric Cancer Markers Detection.Frontiers in chemistry · 2021Review
- Nomogram for predicting pathological complete response to neoadjuvant chemotherapy in patients with advanced gastric cancer.World journal of gastroenterology · 2020Observational
- The significance of preoperative serum carcinoembryonic antigen levels in the prediction of lymph node metastasis and prognosis in locally advanced gastric cancer: a retrospective analysis.BMC gastroenterology · 2020Article
- Carcinoembryonic antigen carrying SLeTheranostics · 2019Article
- Prognostic significance of pretreatment serum carcinoembryonic antigen levels in gastric cancer with pathological lymph node-negative: A large sample single-center retrospective study.World journal of gastroenterology · 2017Article
- Stage Association of Preoperative Serum Carcinoembryonic Antigen with Gastric Adenocarcinoma in Iranian PatientsAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Classic tumor markers in gastric cancer. Current standards and limitations.Clujul medical (1957) · 2015Review
- Adjuvant chemotherapy, p53, carcinoembryonic antigen expression and prognosis after D2 gastrectomy for gastric adenocarcinoma.World journal of gastroenterology · 2014Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate pretreatment serum carcinoembryonic antigen (CEA) as a predictor of survival for patients with locally advanced gastric cancer receiving perioperative chemotherapy.
methodsWe retrospectively studied a cohort of 228 gastric cancer patients who underwent D2 gastrectomy combined with chemotherapy at the Sun Yat-sen University Cancer Center between January 2005 and December 2009. Among them, 168 patients received 6-12 cycles of oxaliplatin-based adjuvant (post-operative) chemotherapy, while 60 received perioperative chemotherapy (2 cycles of FOLFOX6 or XELOX before surgery and 4-10 cycles after surgery). Serum CEA was measured using an enzyme immunoassay. The follow-up lasted until December 2010.
resultsIn the group that had elevated serum CEA, the difference in survival time between patients receiving perioperative chemotherapy and those receiving adjuvant chemotherapy had no statistical significance (P > 0.05). However, in the group that had normal serum CEA, patients receiving perioperative chemotherapy had a longer survival time. In multivariate analysis, T staging and lymph node metastatic rate were independent prognostic factors for the patients. Perioperative chemotherapy improved the overall survival of patients who had a normal pretreatment CEA level (P = 0.070).
conclusionNormal pretreatment serum CEA is a predictor of survival for patients receiving perioperative chemotherapy.
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