ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Early development of electrical excitability in the mouse enteric nervous system.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Functional maturation of enteric neurons derived from human induced pluripotent stem cells.Stem cell reports · 2026Article
- Mature enteric neurons have the capacity to reinnervate the intestine with glial cells as their guide.Neuron · 2024Article
- Sequencing Reveals miRNAs Enriched in the Developing Mouse Enteric Nervous System.Non-coding RNA · 2023Article
- Diminished androgen levels are linked to irritable bowel syndrome and cause bowel dysfunction in mice.The Journal of clinical investigation · 2022Article
- A functional network of highly pure enteric neurons in a dish.Frontiers in neuroscience · 2022Article
- Isolation and transfection of myenteric neurons from mice for patch-clamp applications.Frontiers in molecular neuroscience · 2022Article
- Development of Calbindin- and Calretinin-Immunopositive Neurons in the Enteric Ganglia of Rats.Cellular and molecular neurobiology · 2017Article
- Geminin prevents DNA damage in vagal neural crest cells to ensure normal enteric neurogenesis.BMC biology · 2016Article
- White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies.Developmental biology · 2016Review
- Changes in Nicotinic Neurotransmission during Enteric Nervous System Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Properties of cholinergic and non-cholinergic submucosal neurons along the mouse colon.The Journal of physiology · 2014Article
- Synthesis and evaluation of a 125I-labeled iminodihydroquinoline-derived tracer for imaging of voltage-gated sodium channels.Bioorganic & medicinal chemistry letters · 2013Article
- Transplanted progenitors generate functional enteric neurons in the postnatal colon.The Journal of clinical investigation · 2013Article
- Development and developmental disorders of the enteric nervous system.Nature reviews. Gastroenterology & hepatology · 2013Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural activity is integral to the development of the enteric nervous system (ENS). A subpopulation of neural crest-derived cells expresses pan-neuronal markers at early stages of ENS development (at E10.5 in the mouse). However, the electrical activity of these cells has not been previously characterized, and it is not known whether all cells expressing neuronal markers are capable of firing action potentials (APs). In this study, we examined the activity of "neuron"-like cells (expressing pan-neuronal markers or with neuronal morphology) in the gut of E11.5 and E12.5 mice using whole-cell patch-clamp electrophysiology and compared them to the activity of neonatal and adult enteric neurons. Around 30-40% of neuron-like cells at E11.5 and E12.5 fired APs, some of which were very similar to those of adult enteric neurons. All APs were sensitive to tetrodotoxin (TTX), indicating that they were driven by voltage-gated Na+ currents. Expression of mRNA encoding several voltage-gated Na+ channels by the E11.5 gut was detected using RT-PCR. The density of voltage-gated Na+ currents increased from E11.5 to neonates. Immature active responses, mediated in part by TTX- and lidocaine-insensitive channels, were observed in most cells at E11.5 and E12.5, but not in P0/P1 or adult neurons. However, some cells expressing neuronal markers at E11.5 or E12.5 did not exhibit an active response to depolarization. Spontaneous depolarizations resembling excitatory postsynaptic potentials were observed at E12.5. The ENS is one of the earliest parts of the developing nervous system to exhibit mature forms of electrical activity.
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