Evidence map›Paper›PMID 22875889›Full record

ArticleJournal of clinical microbiology2012

Species identification and antifungal susceptibility testing of Candida bloodstream isolates from population-based surveillance studies in two U.S. cities from 2008 to 2011.

Shawn R Lockhart, Naureen Iqbal, Angela A Cleveland, Monica M Farley, Lee H Harrison, Carol B Bolden, Wendy Baughman, Betsy Stein, Rosemary Hollick, Benjamin J Park and 1 more

Abstract read
In one paragraph

Article in Journal of clinical microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Yeast identification, antifungal susceptibility testing, andJournal of clinical microbiology · 2026
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  11. Mechanism of azole resistance inJournal of medical microbiology · 2025
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  12. Clinical impact of fluconazole-resistantFuture microbiology · 2025
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  13. Heterogeneity ofMicrobiology spectrum · 2025
    Article
  14. Article
  15. Population-Based Active Surveillance for Culture-Confirmed Candidemia - 10 Sites, United States, 2017-2021.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2025
    Article
  16. Fungal Infections in People Who Use Drugs.Open forum infectious diseases · 2025
    Review
  17. Article
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  19. Article
  20. Rapid Identification of Clinically RelevantJournal of fungi (Basel, Switzerland) · 2025
    Article

93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shawn R LockhartMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. gyi2@cdc.gov
Naureen Iqbal
Angela A Cleveland
Monica M Farley
Lee H Harrison
Carol B Bolden
Wendy Baughman
Betsy Stein
Rosemary Hollick
Benjamin J Park
Tom Chiller

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Between 2008 and 2011, population-based candidemia surveillance was conducted in Atlanta, GA, and Baltimore, MD. Surveillance had been previously performed in Atlanta in 1992 to 1993 and in Baltimore in 1998 to 2000, making this the first population-based candidemia surveillance conducted over multiple time points in the United States. From 2,675 identified cases of candidemia in the current surveillance, 2,329 Candida isolates were collected. Candida albicans no longer comprised the majority of isolates but remained the most frequently isolated species (38%), followed by Candida glabrata (29%), Candida parapsilosis (17%), and Candida tropicalis (10%). The species distribution has changed over time; in both Atlanta and Baltimore the proportion of C. albicans isolates decreased, and the proportion of C. glabrata isolates increased, while the proportion of C. parapsilosis isolates increased in Baltimore only. There were 98 multispecies episodes, with C. albicans and C. glabrata the most frequently encountered combination. The new species-specific CLSI Candida MIC breakpoints were applied to these data. With the exception of C. glabrata (11.9% resistant), resistance to fluconazole was very low (2.3% of isolates for C. albicans, 6.2% for C. tropicalis, and 4.1% for C. parapsilosis). There was no change in the proportion of fluconazole resistance between surveillance periods. Overall echinocandin resistance was low (1% of isolates) but was higher for C. glabrata isolates, ranging from 2.1% isolates resistant to caspofungin in Baltimore to 3.1% isolates resistant to anidulafungin in Atlanta. Given the increase at both sites and the higher echinocandin resistance, C. glabrata should be closely monitored in future surveillance.

Indexed as

Antifungal AgentsCandidaCandidemiaCoinfectionGeorgiaHumansMarylandMicrobial Sensitivity TestsAntifungal Agents

Identifiers

PMID22875889
PMCPMC3486211

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.