ArticleBiology letters2013
Temperature, stress and spontaneous mutation in Caenorhabditis briggsae and Caenorhabditis elegans.
Article in Biology letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Bacterial diet influences mutation rate in Pristionchus pacificus.G3 (Bethesda, Md.) · 2026Article
- "Excluded phenotypes" restrict genetic paths toward adaptation in declining populations.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Effects of Extreme Climatic Events on Evolutionary Processes.Global change biology · 2025Review
- Cumulative effects of mutation and selection on susceptibility to bacterial pathogens in Caenorhabditis elegans.Evolution; international journal of organic evolution · 2025Article
- Contrasting mutation patterns in haploid and diploid cells from two yeast species.bioRxiv : the preprint server for biology · 2025Article
- Yeast mutation rates in alternative carbon sources reflect the influence of reactive oxygen species.microPublication biology · 2025Article
- Cisplatin exposure alters tRNA-derived small RNAs but does not affect epimutations in C. elegans.BMC biology · 2023Article
- The divergence of mutation rates and spectra across the Tree of Life.EMBO reports · 2023Review
- Mutation, selection, and the prevalence of the Caenorhabditis elegans heat-sensitive mortal germline phenotype.G3 (Bethesda, Md.) · 2022Article
- Towards a unified framework to study causality in Earth-life systems.Molecular ecology · 2021Article
- Epigenetic modifications affect the rate of spontaneous mutations in a pathogenic fungus.Nature communications · 2021Article
- Multiple Mechanisms Drive the Evolutionary Adaptation ofJournal of fungi (Basel, Switzerland) · 2021Article
- Mutability of mononucleotide repeats, not oxidative stress, explains the discrepancy between laboratory-accumulated mutations and the natural allele-frequency spectrum inGenome research · 2021Article
- Temperature dependence of spontaneous mutation rates.Genome research · 2021Article
- Consequences of mutation accumulation for growth performance are more likely to be resource-dependent at higher temperatures.BMC ecology and evolution · 2021Article
- Fitness effects of spontaneous mutations in a warming world.Evolution; international journal of organic evolution · 2021Article
- Loss of histone H3.3 results in DNA replication defects and altered origin dynamics inGenome research · 2020Article
- Estimation of the SNP Mutation Rate in Two Vegetatively Propagating Species of Duckweed.G3 (Bethesda, Md.) · 2020Article
- Effect of Salt Stress on Mutation and Genetic Architecture for Fitness Components inG3 (Bethesda, Md.) · 2020Article
- Physicochemical Foundations of Life that Direct Evolution: Chance and Natural Selection are not Evolutionary Driving Forces.Life (Basel, Switzerland) · 2020Article
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5 authors.
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Abstract
Mutation rate often increases with environmental temperature, but establishing causality is complicated. Asymmetry between physiological stress and deviation from the optimal temperature means that temperature and stress are often confounded. We allowed mutations to accumulate in two species of Caenorhabditis for approximately 100 generations at 18°C and for approximately 165 generations at 26°C; 26°C is stressful for Caenorhabditis elegans but not for Caenorhabditis briggsae. We report mutation rates at a set of microsatellite loci and estimates of the per-generation decay of fitness (ΔM(w)), the genomic mutation rate for fitness (U) and the average effect of a new mutation (E[a]), assayed at both temperatures. In C. elegans, the microsatellite mutation rate is significantly greater at 26°C than at 18°C whereas in C. briggsae there is only a slight, non-significant increase in mutation rate at 26°C, consistent with stress-dependent mutation in C. elegans. The fitness data from both species qualitatively reinforce the microsatellite results. The fitness results of C. elegans are potentially complicated by selection but also suggest temperature-dependent mutation; the difference between the two species suggests that physiological stress plays a significant role in the mutational process.
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