ArticleThe American journal of clinical nutrition2012
Prospective cohort studies of vitamin B-6 intake and colorectal cancer incidence: modification by time?
Article in The American journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- B vitamin intakes modify the association between particulate air pollutants and incidence of all-cause dementia: Findings from the Women's Health Initiative Memory Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Review
- A Prospective Analysis of Meat Mutagens and Colorectal Cancer in the Nurses' Health Study and Health Professionals Follow-up Study.Environmental health perspectives · 2016Article
- Vitamin B2 intake and colorectal cancer risk; results from the Nurses' Health Study and the Health Professionals Follow-Up Study cohort.International journal of cancer · 2016Article
- Dietary Reference Values for vitamin B6.EFSA journal. European Food Safety Authority · 2016Article
- Postdiagnostic intake of one-carbon nutrients and alcohol in relation to colorectal cancer survival.The American journal of clinical nutrition · 2015Article
- Role of vitamins in gastrointestinal diseases.World journal of gastroenterology · 2015Review
- Dairy food and nutrient intake in different life periods in relation to risk of ovarian cancer.Cancer causes & control : CCC · 2014Article
- Effects of vitamin B6 metabolism on oncogenesis, tumor progression and therapeutic responses.Oncogene · 2013Review
- Vitamin B6 and colorectal cancer: current evidence and future directions.World journal of gastroenterology · 2013Review
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8 authors.
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Abstract
backgroundThe relation between vitamin B-6 intake and colorectal cancer risk remains uncertain.
objectiveWe prospectively evaluated whether a higher vitamin B-6 intake in the remote past is more strongly associated with a lower risk of colorectal cancer than is an intake in the recent past in the Nurses' Health Study and the Health Professionals Follow-Up Study.
designWe assessed vitamin B-6 intake every 4 y by using validated food-frequency questionnaires and followed 86,440 women and 44,410 men for ≤28 y. Cox proportional hazards regression was used to estimate multivariable RRs and 95% CIs.
resultsThe total vitamin B-6 intake was significantly associated with an ∼20-30% lower risk of colorectal cancer in age-adjusted results, but this association became attenuated and nonsignificant after additional adjustment for nondietary and dietary factors. When the highest to lowest quintiles of cumulative total vitamin B-6 intake were compared, RRs (95% CIs) for colorectal cancer were 0.99 (0.80, 1.24; P-trend = 0.55) for women and 0.95 (0.73, 1.23; P-trend = 0.75) for men. For the same comparison, RRs were 0.92 (0.73, 1.16) for total vitamin B-6 intake 0-4 y before diagnosis, 0.99 (0.78, 1.26) for intake 4-8 y before diagnosis, 0.92 (0.71, 1.21) for intake 8-12 y before diagnosis, and 0.93 (0.69, 1.26) for intake 12-16 y before diagnosis in women. Corresponding RRs for men were 0.86 (0.63, 1.17), 0.96 (0.70, 1.32), 0.90 (0.63, 1.29), and 1.16 (0.75, 1.79). Results did not differ by cancer subsite, source of vitamin B-6 (food or supplement), alcohol consumption, or folate intake.
conclusionOur data do not support a strong role of adulthood vitamin B-6 intake in colorectal carcinogenesis in these US health professionals.
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