ArticleJournal of molecular neuroscience : MN2013
Association study of CRP gene and ischemic stroke in a Chinese Han population.
Article in Journal of molecular neuroscience : MN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Systematic review and meta-analysis of stroke blood biomarker data highlights need for more translational research methods.Nature communications · 2026Pooled it
- Association of C-reactive protein gene polymorphisms with the risk of ischemic stroke: A systematic review and meta-analysis.Brain and behavior · 2023Pooled it
- C-reactive Protein -717A>G and -286C>T>A Gene Polymorphism and Ischemic Stroke.Chinese medical journal · 2015Pooled it
- Do CRP gene variants and smoking elevate recurrent stroke risk in minor ischemic stroke patients?European journal of medical research · 2025Article
- Analysis of the Effects ofGenes · 2023Article
- SNP rs3803264 polymorphisms inFrontiers in aging neuroscience · 2023Article
- The potential risk factors of early-onset post-stroke depression from immuno-inflammatory perspective.Frontiers in immunology · 2022Article
- Relationship between CRP gene polymorphisms and ischemic stroke risk: A systematic review and meta-analysis.Open life sciences · 2022Article
- Association of - 757T > C polymorphism of C-reactive protein gene with chronic periodontitis of South Indian population.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Article
- GWAS-Supported CRP Gene Polymorphisms and Functional Outcome of Large Artery Atherosclerotic Stroke in Han Chinese.Neuromolecular medicine · 2018Article
- C-Reactive Protein Gene Contributes to the Genetic Susceptibility of Hemorrhagic Stroke in Men: a Case-Control Study in Chinese Han Population.Journal of molecular neuroscience : MN · 2017Article
- C-reactive protein gene and Toll-like receptor 4 gene polymorphisms can relate to the development of psoriatic arthritis.Clinical rheumatology · 2015Article
- CRP gene polymorphism contributes genetic susceptibility to dyslipidemia in Han Chinese population.Molecular biology reports · 2014Article
- Polymorphisms in the PTX1 may not be associated with ischemic stroke susceptibility.International journal of clinical and experimental medicine · 2014Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
High-sensitivity C-reactive protein (hsCRP) was reported as a strong, independent predictor of future myocardial infarction and stroke. It is of importance to illustrate the conformance of CRP genetic variation, increment of plasma hsCRP and cerebral events. A case-control study including 548 patients with acute ischemic stroke and 993 age-matched controls from community-based population was conducted and four tagging SNPs (tagSNPs) were genotyped. Multiple logistic regression was applied to evaluate the association of CRP gene and stroke hsCRP elevation with adjustment for covariates. The results indicated that rs3093059 and rs3091244 presented statistical associations with ischemic stroke. Odds ratios (ORs) (95 % confidence interval [CI]) of additive model, dominant model and minor allele at rs3093059 were 0.697 (0.528-0.921), 0.671 (0.487-0.923) and 0.811 (0.666-0.988), and ORs (95 % CI) of dominant model at rs3091244 was 0.728 (0.536-0.988), after adjusting for covariates. But there were no significant differences of genotype or allele frequencies of the four SNPs observed between hypertension (HT) and normal blood pressure (NBP) groups. Further analyses indicated the genetic variations of rs876537 and rs3093059 were positively associated with increased square root transformed hsCRP and hsCRP elevation (≥3 mg/l) in ischemic stroke patients, and rs876537 and rs3091244 were associated with hsCRP elevation in controls as well. Our finding suggests that the CRP genetic polymorphisms were associated with decreased risk of ischemic stroke and elevated plasma hsCRP and further replication study and functional research would be warranted.
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