ArticleDevelopment (Cambridge, England)2012
Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
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- An improved organ explant culture method reveals stem cell lineage dynamics in the adulteLife · 2022Article
- Reciprocal EGFR signaling in the anchor cell ensures precise inter-organ connection during Caenorhabditis elegans vulval morphogenesis.Development (Cambridge, England) · 2022Article
- MRCK: a master regulator of tissue remodeling or another 'ROCK' in the epithelial block?Tissue barriers · 2021Review
- Predictive significance of STK17A in patients with gastric cancer and association with gastric cancer cell proliferation and migration.Oncology reports · 2021Article
- A combination of Notch signaling, preferential adhesion and endocytosis induces a slow mode of cell intercalation in the Drosophila retina.Development (Cambridge, England) · 2021Article
- A modifier screen identifies regulators of cytoskeletal architecture as mediators of Shroom-dependent changes in tissue morphology.Biology open · 2021Article
- Drak/STK17A Drives Neoplastic Glial Proliferation through Modulation of MRLC Signaling.Cancer research · 2019Article
- PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization.Cellular and molecular life sciences : CMLS · 2018Review
- An apical MRCK-driven morphogenetic pathway controls epithelial polarity.Nature cell biology · 2017Article
- Regulatory mechanisms of EGFR signalling during Drosophila eye development.Cellular and molecular life sciences : CMLS · 2016Review
- Drak Is Required for Actomyosin Organization During Drosophila Cellularization.G3 (Bethesda, Md.) · 2016Article
- Mechanics of tissue compaction.Seminars in cell & developmental biology · 2015Review
- Square Cell Packing in the Drosophila Embryo through Spatiotemporally Regulated EGF Receptor Signaling.Developmental cell · 2015Article
- Spatiotemporal control of epithelial remodeling by regulated myosin phosphorylation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The roles and regulation of multicellular rosette structures during morphogenesis.Development (Cambridge, England) · 2014Review
- Eye development.Methods (San Diego, Calif.) · 2014Review
- Rho GTPase and Shroom direct planar polarized actomyosin contractility during convergent extension.The Journal of cell biology · 2014Article
- Insights into the functions of the death associated protein kinases from C. elegans and other invertebrates.Apoptosis : an international journal on programmed cell death · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Morphogenesis of epithelial tissues relies on the interplay between cell division, differentiation and regulated changes in cell shape, intercalation and sorting. These processes are often studied individually in relatively simple epithelia that lack the complexity found during organogenesis when these processes might all coexist simultaneously. To address this issue, we are making use of the developing fly retinal neuroepithelium. Retinal morphogenesis relies on a coordinated sequence of interdependent morphogenetic events that includes apical cell constriction, localized alignment of groups of cells and ommatidia morphogenesis coupled to neurogenesis. Here, we use live imaging to document the sequence of adherens junction (AJ) remodelling events required to generate the fly ommatidium. In this context, we demonstrate that the kinases Rok and Drak function redundantly during Myosin II-dependent cell constriction, subsequent multicellular alignment and AJ remodelling. In addition, we show that early multicellular patterning characterized by cell alignment is promoted by the conserved transcription factor Atonal (Ato). Further ommatidium patterning requires the epidermal growth factor receptor (EGFR) signalling pathway, which transcriptionally governs rok- and Drak-dependent AJ remodelling while also promoting neurogenesis. In conclusion, our work reveals an important role for Drak in regulating AJ remodelling during retinal morphogenesis. It also sheds new light on the interplay between Ato, EGFR-dependent transcription and AJ remodelling in a system in which neurogenesis is coupled with cell shape changes and regulated steps of cell intercalation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.