ArticleMucosal immunology2013
Altered generation of induced regulatory T cells in the FVB.mdr1a-/- mouse model of colitis.
Article in Mucosal immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- H7F ameliorates DSS-induced colitis through restoration of intestinal barrier function and inhibition of IL-17/NF-κb signaling.Frontiers in pharmacology · 2026Article
- T Regulatory Cells in Inflammatory Bowel Disease-Are They Major Players?International journal of molecular sciences · 2025Review
- P-glycoprotein expression skews mitochondrial dye measurements in T cells.Frontiers in immunology · 2025Article
- P-glycoprotein: new insights into structure, physiological function, regulation and alterations in disease.Heliyon · 2022Review
- ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance.Cancer biology & medicine · 2020Review
- Physiological expression and function of the MDR1 transporter in cytotoxic T lymphocytes.The Journal of experimental medicine · 2020Article
- Steroids, Pregnancy and Fetal Development.Frontiers in immunology · 2019Review
- A Review of the Scaffold Protein Menin and its Role in Hepatobiliary Pathology.Gene expression · 2017Review
- P-glycoprotein multidrug transporter in inflammatory bowel diseases: More questions than answers.World journal of gastroenterology · 2017Article
- Altered T-Cell Balance in Lymphoid Organs of a Mouse Model of Colorectal Cancer.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2016Article
- Vagotomy affects the development of oral tolerance and increases susceptibility to develop colitis independently of the alpha-7 nicotinic receptor.Molecular medicine (Cambridge, Mass.) · 2016Article
- Galectin-3 suppresses mucosal inflammation and reduces disease severity in experimental colitis.Journal of molecular medicine (Berlin, Germany) · 2016Article
- Role of regulatory T cell in the pathogenesis of inflammatory bowel disease.World journal of gastroenterology · 2016Review
- Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology.World journal of gastroenterology · 2015Article
- Animal models of inflammatory bowel disease: a review.Inflammopharmacology · 2014Review
- Consumption of acidic water alters the gut microbiome and decreases the risk of diabetes in NOD mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2014Article
- P-glycoprotein and drug resistance in systemic autoimmune diseases.International journal of molecular sciences · 2014Review
- Induced and natural regulatory T cells in the development of inflammatory bowel disease.Inflammatory bowel diseases · 2013Review
- Animal models of ulcerative colitis and their application in drug research.Drug design, development and therapy · 2013Review
- MDR1 in immunity: friend or foe?OncoimmunologyReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The FVB.mdr1a(-/-) mouse, lacking the small molecule pump P-glycoprotein (P-gp), is a commonly used model for the study of spontaneous T cell-mediated colitis. In addition, MDR1 polymorphisms and P-gp deficiency in humans have been linked to the development of ulcerative colitis. We now demonstrate that mice with P-gp deficiency have decreased levels of Foxp3(+) regulatory T cells (Tregs) in the intestinal lamina propria. This decrease is not due to either increased Treg apoptosis, altered Treg trafficking, or enhanced Treg plasticity to become Foxp3(+)IL-17(+) cells. Instead, P-gp deficiency appears to restrict the development of induced Treg cells (iTregs), as fewer Foxp3(+) iTregs developed from naive FVB.mdr1a(-/-) T cells both upon transforming growth factor-β (TGF-β) treatment in vitro and after adoptive transfer into FVB.rag2(-/-) recipients. Rather, in vitro TGF-β treatment results in a IL-17(+)CD4(+) T cell. This failure of iTregs to develop explains the decrease in Foxp3(+) Tregs in the FVB.mdr1a(-/-) intestine, representing a need to investigate this novel disease mechanism in human inflammatory bowel disease patients with MDR1 polymorphisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.