ArticleAIDS (London, England)2013
Effects of aging and smoking on carotid intima-media thickness in HIV-infection.
Article in AIDS (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The effect of HIV infection, antiretroviral therapy on carotid intima-media thickness: A systematic review and meta-analysis.Life sciences · 2019Pooled it
- Prevalence of non-HIV cancer risk factors in persons living with HIV/AIDS: a meta-analysis.AIDS (London, England) · 2016Pooled it
- Combined effects of smoking and HIV infection on the occurrence of aging-related manifestations.Scientific reports · 2023Article
- Subclinical atherosclerosis and associated risk factors among HIV-infected adults in Jos, North Central Nigeria: a cross-sectional study.The Pan African medical journal · 2020Article
- Association Between Carotid Artery Intima-Media Thickness and Combinations of Mild Cognitive Impairment and Pre-Frailty in Older Adults.International journal of environmental research and public health · 2019Article
- Comparison of visceral fat measurement by dual-energy X-ray absorptiometry to computed tomography in HIV and non-HIV.Nutrition & diabetes · 2019Article
- Article
- Immunosuppression and HIV Viremia Associated with More Atherogenic Lipid Profile in Older People with HIV.AIDS research and human retroviruses · 2019Observational
- The effects of HIV and smoking on aortic and splenic inflammation.AIDS (London, England) · 2018Article
- Article
- HIV Infection and Carotid Artery Intima-media Thickness: Pooled Analyses Across 5 Cohorts of the NHLBI HIV-CVD Collaborative.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Article
- Cardiovascular disease risk in an aging HIV population: not just a question of biology.Current opinion in HIV and AIDS · 2014Review
- HIV and aging: emerging research issues.Current opinion in HIV and AIDS · 2014Review
- Substance use in older HIV-infected patients.Current opinion in HIV and AIDS · 2014Review
- Subclinical atherosclerosis among HIV-infected adults attending HIV/AIDS care at two large ambulatory HIV clinics in Uganda.PloS one · 2014Article
- The effect of HIV infection on longitudinal lung function decline among IDUs: a prospective cohort.AIDS (London, England) · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesTo investigate the effects of aging and smoking on carotid intima-media thickness (cIMT) among patients with and without HIV.
methodsData from a community sample of HIV-infected and HIV-uninfected participants were analyzed. Carotid intima-media thickness was measured via carotid ultrasound and smoking history was obtained via patient interview.
resultsData on 166 male and female participants with stable HIV-infection and 152 healthy HIV-uninfected participants were analyzed. Among the HIV-infected and HIV-uninfected participants, a significant association was observed between age and cIMT [r = 0.51, P < 0.0001 (HIV), r = 0.39, P < 0.0001, (non-HIV)], and between smoking burden and cIMT [r = 0.42, P < 0.0001 (HIV), r = 0.24, P = 0.003 (non-HIV)]. In multivariate regression modeling among all participants (HIV and non-HIV), a significant three-way interaction was observed between age, smoking burden, and HIV status with respect to cIMT (P < 0.010), controlling for sex, race, and traditional cardiovascular disease (CVD) risk factors, such that increased cIMT was associated with increased smoking burden and age to a greater degree among HIV-infected vs. HIV-uninfected participants. Among HIV-infected participants a significant interaction between smoking burden and age with respect to cIMT was seen (P = 0.027) controlling for race, sex, CVD risk factors, immunological function, and antiretroviral therapy use.
conclusionA significant interaction between HIV, age, and smoking on cIMT was observed, suggesting that HIV-infection modifies the relationship of age and smoking on cIMT in this population. These findings emphasize the need to encourage smoking cessation in this population, due to its deleterious effect on subclinical atherosclerosis in older HIV-infected patients.
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