ArticleBMC genomics2012
The carbon starvation response of Aspergillus niger during submerged cultivation: insights from the transcriptome and secretome.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 143 citations in OpenAlex.
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- Multi-omics analysis of Trichoderma reesei mutant with high glucanase activity.Scientific reports · 2025Article
- Human health risk assessment for microbial pesticides in the EU: challenges and perspectives.Environmental health : a global access science source · 2025Review
- Adjusting Aspergillus niger pellet diameter, population heterogeneity, and core architecture during shake flask cultivation.Biotechnology for biofuels and bioproducts · 2025Article
- Morphogenesis, starvation, and light responses in a mushroom-forming fungus revealed by long-read sequencing and extensive expression profiling.Cell genomics · 2025Article
- Comprehensive phenotypic analysis of multiple gene deletions of α-glucan synthase and Crh-transglycosylase gene families inCell surface (Amsterdam, Netherlands) · 2025Article
- Multi-omics analysis provides insights into mechanisms of intestinal fungi adaptation to dietary carbohydrates.Current research in microbial sciences · 2025Article
- Engineering the secretome of Aspergillus niger for cellooligosaccharides production from plant biomass.Microbial cell factories · 2024Article
- Carbon and Nitrogen Sources Influence Parasitic Responsiveness inJournal of fungi (Basel, Switzerland) · 2024Article
- The antifungal peptide AnAFP fromFrontiers in microbiology · 2024Article
- Adaptation to glucose starvation is associated with molecular reorganization of the circadian clock ineLife · 2023Article
- Analysis and modification of central carbon metabolism inFrontiers in microbiology · 2023Article
- Transcription FactorJournal of fungi (Basel, Switzerland) · 2022Article
- Evolutionary Morphogenesis of Sexual Fruiting Bodies in Basidiomycota: Toward a New Evo-Devo Synthesis.Microbiology and molecular biology reviews : MMBR · 2022Review
- The International Space Station Environment Triggers Molecular Responses inFrontiers in microbiology · 2022Article
- The Cultivation Method Affects the Transcriptomic Response of Aspergillus niger to Growth on Sugar Beet Pulp.Microbiology spectrum · 2021Article
- Blocking utilization of major plant biomass polysaccharides leads Aspergillus niger towards utilization of minor components.Microbial biotechnology · 2021Article
- Production of a β-Glucosidase-Rich Cocktail fromJournal of fungi (Basel, Switzerland) · 2021Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFilamentous fungi are confronted with changes and limitations of their carbon source during growth in their natural habitats and during industrial applications. To survive life-threatening starvation conditions, carbon from endogenous resources becomes mobilized to fuel maintenance and self-propagation. Key to understand the underlying cellular processes is the system-wide analysis of fungal starvation responses in a temporal and spatial resolution. The knowledge deduced is important for the development of optimized industrial production processes.
resultsThis study describes the physiological, morphological and genome-wide transcriptional changes caused by prolonged carbon starvation during submerged batch cultivation of the filamentous fungus Aspergillus niger. Bioreactor cultivation supported highly reproducible growth conditions and monitoring of physiological parameters. Changes in hyphal growth and morphology were analyzed at distinct cultivation phases using automated image analysis. The Affymetrix GeneChip platform was used to establish genome-wide transcriptional profiles for three selected time points during prolonged carbon starvation. Compared to the exponential growth transcriptome, about 50% (7,292) of all genes displayed differential gene expression during at least one of the starvation time points. Enrichment analysis of Gene Ontology, Pfam domain and KEGG pathway annotations uncovered autophagy and asexual reproduction as major global transcriptional trends. Induced transcription of genes encoding hydrolytic enzymes was accompanied by increased secretion of hydrolases including chitinases, glucanases, proteases and phospholipases as identified by mass spectrometry.
conclusionsThis study is the first system-wide analysis of the carbon starvation response in a filamentous fungus. Morphological, transcriptomic and secretomic analyses identified key events important for fungal survival and their chronology. The dataset obtained forms a comprehensive framework for further elucidation of the interrelation and interplay of the individual cellular events involved.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.