ArticleMalaria journal2012
Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection.
Article in Malaria journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 79 citations in OpenAlex.
- Allicin-based biomimetic nanoparticles of the erythrocyte membrane for the delivery of lumefantrine to enhance its antimalarial effect.International journal of pharmaceutics: X · 2026Article
- Identifying immunostimulatory herbal supplements that may flare autoimmune skin diseases: a systematic scoping review.Lupus science & medicine · 2025Article
- Antimicrobial Activity of Natural Extracts Against Catheter-Colonizing Methicillin-ResistantBiomedicines · 2025Article
- Antiplasmodial and immunomodulatory activities of dichloromethane extract ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Article
- Exploring the Therapeutic Potential of Traditional Medicinal Foods in Cancer Treatment: Molecular Evidence and Bioactivities.Current topics in medicinal chemistry · 2025Review
- Anthelmintic Activity and Pathophysiological Effect ofJournal of parasitology research · 2025Article
- Natural Ingredients to Improve Immunity.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Thiosulfinate-EnrichedInternational journal of molecular sciences · 2023Article
- Essential Oils and COVID-19.Molecules (Basel, Switzerland) · 2022Review
- Plant Derived Immunomodulators; A Critical Review.Advanced pharmaceutical bulletin · 2022Review
- Evaluation of Allicin Against Alveolar Echinococcosis In Vitro and in a Mouse Model.Acta parasitologica · 2022Article
- Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment.Frontiers in pharmacology · 2022Review
- Effect of Allicin and Artesunate Combination Treatment on Experimental Mice Infected withVeterinary medicine international · 2022Article
- Development of Broad-Spectrum Antiviral Agents-Inspiration from Immunomodulatory Natural Products.Viruses · 2021Review
- The Potential of Toll-Like Receptors to Modulate Avian Immune System: Exploring the Effects of Genetic Variants and Phytonutrients.Frontiers in genetics · 2021Review
- The effects of allium sativum on immunity within the scope of COVID-19 infection.Medical hypotheses · 2020Article
- Health Benefits of Plant-Derived Sulfur Compounds, Glucosinolates, and Organosulfur Compounds.Molecules (Basel, Switzerland) · 2020Review
- Review: antimicrobial properties of allicin used alone or in combination with other medications.Folia microbiologica · 2020Review
- Dietary Allicin Improved the Survival and Growth of Large Yellow Croaker (Frontiers in physiology · 2020Article
- Characterization of γ-glutamyltranspeptidases from dormant garlic and onion bulbs.Food science & nutrition · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring malaria infection, multiple pro-inflammatory mediators including IFN-γ, TNF and nitric oxide (NO) play a crucial role in the protection against the parasites. Modulation of host immunity is an important strategy to improve the outcome of malaria infection. Allicin is the major biologically active component of garlic and shows anti-microbial activity. Allicin is also active against protozoan parasites including Plasmodium, which is thought to be mediated by inhibiting cysteine proteases. In this study, the immunomodulatory activities of allicin were assessed during acute malaria infection using a rodent malaria model Plasmodium yoelii 17XL.
methodsTo determine whether allicin modulates host immune responses against malaria infection, mice were treated with allicin after infection with P. yoelii 17XL. Mortality was checked daily and parasitaemia was determined every other day. Pro-inflammatory mediators and IL-4 were quantified by ELISA, while NO level was determined by the Griess method. The populations of dendritic cells (DCs), macrophages, CD4+ T and regulatory T cells (Treg) were assessed by FACS.
resultsAllicin reduced parasitaemia and prolonged survival of the host in a dose-dependent manner. This effect is at least partially due to improved host immune responses. Results showed that allicin treatment enhanced the production of pro-inflammatory mediators such as IFN-γ, TNF, IL-12p70 and NO. The absolute numbers of CD4+ T cells, DCs and macrophages were significantly higher in allicin-treated mice. In addition, allicin promoted the maturation of CD11c+ DCs, whereas it did not cause major changes in IL-4 and the level of anti-inflammatory cytokine IL-10.
conclusionsAllicin could partially protect host against P. yoelii 17XL through enhancement of the host innate and adaptive immune responses.
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Registered trials
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