ArticleThe Journal of infectious diseases2012
Influence of host genetics and environment on nasal carriage of staphylococcus aureus in danish middle-aged and elderly twins.
Article in The Journal of infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 58 citations in OpenAlex.
- A Double-blind Randomized Trial of Oral Chlorhexidine Gluconate for Treatment of OralOpen forum infectious diseases · 2026Trial
- Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population.PloS one · 2019Trial
- Functionally enriched human polymorphisms associate to species in the chronic wound microbiome.NPJ biofilms and microbiomes · 2025Article
- Staphylococci in high resolution: Capturing diversity within the human nasal microbiota.Cell reports · 2025Article
- Staphylococcus aureus colonisation and strategies for decolonisation.The Lancet. Microbe · 2024Review
- A genome-wide association study reveals the relationship between human genetic variation and the nasal microbiome.Communications biology · 2024Article
- Nasal commensals reduce Staphylococcus aureus proliferation by restricting siderophore availability.The ISME journal · 2024Article
- Article
- Are Staphylococcus aureus Carrier Types Evidence of Population Heterogeneity?American journal of epidemiology · 2023Article
- SaQuant: a real-time PCR assay for quantitative assessment of Staphylococcus aureus.BMC microbiology · 2021Article
- Determinants of Staphylococcus aureus carriage in the developing infant nasal microbiome.Genome biology · 2020Article
- Article
- Cohort description: The Danish Blood DonorClinical epidemiology · 2019Article
- Bacterial microbiota of the nasal passages across the span of human life.Current opinion in microbiology · 2018Review
- Review
- The commensal lifestyle of Staphylococcus aureus and its interactions with the nasal microbiota.Nature reviews. Microbiology · 2017Review
- Evaluating genetic susceptibility to Staphylococcus aureus bacteremia in African Americans using admixture mapping.Genes and immunity · 2017Article
- Commensal-Pathogen Interactions along the Human Nasal Passages.PLoS pathogens · 2016Review
- Gene, environment, microbiome and mucosal immune tolerance in rheumatoid arthritis.Rheumatology (Oxford, England) · 2016Review
- Impact of Bacterial and Human Genetic Variation on Staphylococcus aureus Infections.PLoS pathogens · 2016Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundNasal carriage is a major risk factor for Staphylococcus aureus infection. Approximately, one-quarter of adults carry S. aureus. However, the role of host genetics on S. aureus nasal carriage is unknown.
methodsNasal swabs were obtained from a national cohort of middle-aged and elderly Danish twins. Subjects colonized with S. aureus were identified by growth on selective plates and spa typing. A second sample was obtained from twins initially concordant for carriage. Twins found to again be colonized with S. aureus were defined as persistent carriers.
resultsThe prevalence of S. aureus carriage among 617 twin pairs (monozygotic/dizygotic pairs: 112/505) was 26.3% (95% confidence interval [CI], 24.0%-28.9%). The concordance rate for carriage did not differ significantly between pairs of monozygotic (37.5%; 95% CI, 22.3%-53.8%) twins and same sex (24.2%; 95% CI, 15.4%-34.5%), and opposite sex (21.4%; 95% CI, 12.0%-33.4%) dizygotic twins. Despite shared childhoods, only 1 of 617 pairs was concordant with respect to lineage. Although heritability increased for S. aureus and lineage persistency, no significant heritability was detected.
conclusionIn this study, host genetic factors exhibited only a modest influence on the S. aureus carrier state of middle-aged and elderly individuals.
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