Trial reportExperimental physiology2013
Sweat loss during heat stress contributes to subsequent reductions in lower-body negative pressure tolerance.
Trial report in Experimental physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Meta-analysis of heat-induced changes in cardiac function from over 400 laboratory-based heat exposure studies.Nature communications · 2025Pooled it
- Postural Instability Is Greater in Men with Type 2 Diabetes after Exertional Heat Stress.Medicine and science in sports and exercise · 2026Trial
- The Effects of Taekwondo Training on Peripheral Neuroplasticity-Related Growth Factors, Cerebral Blood Flow Velocity, and Cognitive Functions in Healthy Children: A Randomized Controlled Trial.International journal of environmental research and public health · 2017Trial
- Hemodynamic Stability to Surface Warming and Cooling During Sustained and Continuous Simulated Hemorrhage in Humans.Shock (Augusta, Ga.) · 2016Trial
- Impairments in central cardiovascular function contribute to attenuated reflex vasodilation in aged skin.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Trial
- Hypercapnia-induced increases in cerebral blood flow do not improve lower body negative pressure tolerance during hyperthermia.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Trial
- The impact of mild hypohydration and sex on the cardiovascular responses to progressive lower-body negative pressure.European journal of applied physiology · 2026Article
- Effects of heat exposure on self-reported heat strain symptoms among pregnant and postpartum women in South Africa.npj digital public health · 2026Article
- Compensatory reserve index during central hypovolemia and volume loading in healthy young and older hyperthermic adults: A pilot study.Physiological reports · 2024Article
- Acute fasting reduces tolerance to progressive central hypovolemia in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Heat Safety in the Workplace: Modified Delphi Consensus to Establish Strategies and Resources to Protect the US Workers.GeoHealth · 2021Article
- Central Hypovolemia Detection During Environmental Stress-A Role for Artificial Intelligence?Frontiers in physiology · 2021Review
- Impact of environmental stressors on tolerance to hemorrhage in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Hemostatic responses to exercise, dehydration, and simulated bleeding in heat-stressed humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Heat Adaptation in Military Personnel: Mitigating Risk, Maximizing Performance.Frontiers in physiology · 2019Review
- Volume loading augments cutaneous vasodilatation and cardiac output of heat stressed older adults.The Journal of physiology · 2017Article
- Sympathetic neural and hemodynamic responses to head-up tilt during isoosmotic and hyperosmotic hypovolemia.Journal of neurophysiology · 2017Article
- Plasma hyperosmolality improves tolerance to combined heat stress and central hypovolemia in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Elevated skin and core temperatures both contribute to reductions in tolerance to a simulated haemorrhagic challenge.Experimental physiology · 2017Article
- Mechanisms of orthostatic intolerance during heat stress.Autonomic neuroscience : basic & clinical · 2016Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The contribution of sweating to heat stress-induced reductions in haemorrhagic tolerance is not known. This study tested the hypothesis that fluid loss due to sweating contributes to reductions in simulated haemorrhagic tolerance in conditions of heat stress. Eight subjects (35 ± 8 years old; 77 ± 5 kg) underwent a normothermic time control and two heat stress trials (randomized). The two heat stress trials were as follows: (i) with slow intravenous infusion of lactated Ringer solution sufficient to offset sweat loss (IV trial); or (ii) without intravenous infusion (dehydration; DEH trial). Haemorrhage was simulated via progressive lower-body negative pressure (LBNP) to presyncope after core body (intestinal) temperature was raised by ~1.5 °C using a water-perfused suit or a normothermic time control period. The LBNP tolerance was quantified via a cumulative stress index. Middle cerebral artery blood velocity (transcranial Doppler) and mean blood pressure (Finometer®) were measured continuously. Relative changes in plasma volume were calculated from haematocrit and haemoglobin. Increases in core body temperature and sweat loss (~1.6% body mass deficit) were similar (P > 0.05) between heat stress trials. Slow intravenous infusion (1.2 ± 0.3 litres) prevented heat-induced reductions in plasma volume (IV trial, -0.6 ± 6.1%; and DEH trial, -6.6 ± 5.1%; P = 0.01). Intravenous infusion improved LBNP tolerance (632 ± 64 mmHg min) by ~20% when compared with the DEH trial (407 ± 117 mmHg min; P = 0.01), yet tolerance remained 44% lower in the IV trial relative to the time control normothermic trial (1138 ± 183 mmHg min; P < 0.01). These data indicate that although sweat-induced dehydration impairs simulated haemorrhagic tolerance, this impairment is secondary to the negative impact of heat stress itself.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.