ReviewAdvances in experimental medicine and biology2013
Spermatogenesis.
Review in Advances in experimental medicine and biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 108 citations in OpenAlex.
- Actin Cytoskeleton Dysregulation Links Testicular and Sperm Dysfunction in Type 1 Diabetes.International journal of molecular sciences · 2026Article
- SPSP-1 is a sperm protein required for C. elegans hermaphrodite sperm production and embryogenesis.Biology open · 2026Article
- Distinct functions in fertility and patterns of paternal incorporation of the histone H2A variants HTAS-1 and HTZ-1 in C. elegans.Genetics · 2026Article
- Sperm activation for fertilization requires robust activity of the TAT-5 lipid flippase.Developmental biology · 2025Article
- The Caenorhabditis elegans spe-21 gene that encodes a palmitoyltransferase is necessary for spermiogenesis.Developmental biology · 2025Article
- Teratozoospermia and Embryo Development: The Significance of Sperm Selection in In Vitro Fertilization Success.Journal of clinical medicine · 2025Article
- Impact of Type 1 Diabetes on Testicular Microtubule Dynamics, Sperm Physiology, and Male Reproductive Health in Rat.International journal of molecular sciences · 2025Article
- UtilizingJournal of developmental biology · 2025Review
- Article
- Circular RNAs: novel noncoding players in male infertility.Hereditas · 2024Review
- TMEM232 is required for the formation of sperm flagellum and male fertility in mice.Cell death & disease · 2024Article
- Transcriptomic Analysis of the Spatiotemporal Axis of Oogenesis and Fertilization inbioRxiv : the preprint server for biology · 2024Article
- Novel underlying genetic markers for asthenozoospermia due to abnormal spermatogenesis and reproductive organ inflammation.Experimental and therapeutic medicine · 2024Article
- Testicular fat deposition attenuates reproductive performance via decreased follicle-stimulating hormone level and sperm meiosis and testosterone synthesis in mouse.Animal bioscience · 2024Article
- Transcriptomic analysis of the spatiotemporal axis of oogenesis and fertilization inFrontiers in cell and developmental biology · 2024Article
- Article
- Measuring Embryonic Viability and Brood Size in Caenorhabditis elegans.Journal of visualized experiments : JoVE · 2023Article
- Testis-Specific Protein Y-Encoded (TSPY) Is Required for Male Early Embryo Development inInternational journal of molecular sciences · 2023Article
- Male-specific roles of lincRNA inFrontiers in cell and developmental biology · 2023Article
- Bioinformatics analysis identifies potential hub genes and crucial pathways in the pathogenesis of asthenozoospermia.BMC medical genomics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
During spermatogenesis, pluripotent germ cells differentiate to become efficient delivery vehicles to the oocyte of paternal DNA. Though male and female germ cells both undergo meiosis to produce haploid complements of DNA, at the same time they also each undergo distinct differentiation processes that result in either sperm or oocytes. This review will discuss our current understanding of mechanisms of sperm formation and differentiation in Caenorhabditis elegans gained from studies that employ a combination of molecular, transcriptomic, and cell biological approaches. Many of these processes also occur during spermatogenesis in other organisms but with differences in timing, molecular machinery, and morphology. In C. elegans, sperm differentiation is implemented by varied modes of gene regulation, including the genomic organization of genes important for sperm formation, the generation of sperm-specific small RNAs, and the interplay of specific transcriptional activators. As sperm formation progresses, chromatin is -systematically remodeled to allow first for the implementation of differentiation programs, then for sperm-specific DNA packaging required for transit of paternal genetic and epigenetic information. Sperm also exhibit distinctive features of -meiotic progression, including the formation of a unique karyosome state and the centrosomal-based segregation of chromosomes during symmetric meiotic -divisions. Sperm-specific organelles are also assembled and remodeled as cells complete -meiosis and individualize in preparation for activation, morphogenesis, and the acquisition of motility. Finally, in addition to DNA, sperm contribute specific cellular factors that contribute to successful embryogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.