Evidence map›Paper›PMID 22872371›Full record

ReviewCurrent atherosclerosis reports2012

Molecular imaging in atherosclerosis: FDG PET.

David Rosenbaum, Antoine Millon, Zahi A Fayad

Abstract readReview
In one paragraph

Review in Current atherosclerosis reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. [EJNMMI research · 2026
    Review
  3. Feasibility of [Diagnostics (Basel, Switzerland) · 2025
    Article
  4. Contribution ofCurrent issues in molecular biology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Feasibility of whole-body 2-deoxy-2-[Annals of nuclear medicine · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Comparing Semiquantitative and Qualitative Methods of VascularJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Observational
  16. Pulmonary ArteryJACC. Cardiovascular imaging · 2022
    Article
  17. PET-Based Imaging withDiagnostics (Basel, Switzerland) · 2021
    Review
  18. Review
  19. Vascular Uptake onYonsei medical journal · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

David RosenbaumUnité de Prévention Cardiovasculaire, Pole Cardiologie Métabolisme, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 83, Boulevard de l'Hôpital, 75651 Paris Cedex 13, France. david.rosenbaum@psl.aphp.fr
Antoine Millon
Zahi A Fayad

Funding

MOUNT SINAI INSTITUTES FOR CLINICAL AND TRANSLATIONAL SCIENCESUL1RR029887 · NCRR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SAMPSON, HUGH A · 2009 to 2011
$19.2M
Mount Sinai Institutes for Clinical and Translational SciencesUL1TR000067 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SAMPSON, HUGH A · 2012 to 2014
$16.5M
MR/PET Imaging of coronary atherosclerosisR01HL071021 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FAYAD, ZAHI A. · 2002 to 2019
$7.8M
Theranostic HDL nanoparticles for inflammatory macrophages in atherosclerosisR01EB009638 · NIBIB · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAYAD, ZAHI A. · 2009 to 2016
$4.6M
Nanoparticles for Molecular MRI of AtherosclerosisR01HL078667 · NHLBI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FAYAD, ZAHI A. · 2004 to 2008
$2.5M
NCATS NIH HHS UL1 TR000067NCRR NIH HHS UL1 RR029887NCRR NIH HHS UL1RR029887NHLBI NIH HHS HHSN268201000045CNHLBI NIH HHS R01 HL071021NHLBI NIH HHS R01 HL078667NIBIB NIH HHS R01 EB009638
6 · The paper itself

Abstract

18F-FDG PET is a new noninvasive tool for inflammation functional imaging. Low spatial resolution is now compensated by coregistration with CT or MRI. New mechanistic insights have emerged from animal and histology to explain the obtained signals by hypoxia, macrophage infiltration, and differentiation. Mixed results have been found in biomarkers studies. Interesting data have come recently linking plaque anatomy and function in carotids and in aortic aneurysms as well as inflammation and events. In coronary arteries, plaque assessment is still hampered by myocardium uptake but developments are being made. 18-FDG PET has been able to monitor inflammation before and after several therapies in animals and humans but to date the lack of standardization and the absence of prospective event-driven studies prevent this promising technique to be used in clinical practice.

Indexed as

Fluorodeoxyglucose F18AnimalsAtherosclerosisHumansInflammationMolecular ImagingPositron-Emission TomographyFluorodeoxyglucose F18

Identifiers

PMID22872371
PMCPMC3576137

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.