ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2012
Gene expression profiling in human craniosynostoses: a tool to investigate the molecular basis of suture ossification.
Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Single-cell analysis identifies a key role for Hhip in murine coronal suture development.Nature communications · 2021Article
- Imaging in craniosynostosis: when and what?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Review
- Article
- Overactive autophagy is a pathological mechanism underlying premature suture ossification in nonsyndromic craniosynostosis.Scientific reports · 2018Article
- Muscle Expression of SOD1(G93A) Modulates microRNA and mRNA Transcription Pattern Associated with the Myelination Process in the Spinal Cord of Transgenic Mice.Frontiers in cellular neuroscience · 2015Article
- Closing the Gap: Genetic and Genomic Continuum from Syndromic to Nonsyndromic Craniosynostoses.Current genetic medicine reports · 2014Article
- Characterization of distinct classes of differential gene expression in osteoblast cultures from non-syndromic craniosynostosis bone.Journal of genomics · 2014Article
- RUNX3 is a prognostic marker and potential therapeutic target in human breast cancer.Journal of cancer research and clinical oncology · 2013Article
- Gene expression profiling as a tool to investigate the molecular machinery activated during hippocampal neurodegeneration induced by trimethyltin (TMT) administration.International journal of molecular sciences · 2013Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionNon-syndromic craniosynostoses (NSC) occur as isolated skull malformations due to the premature ossification of one (single-suture forms) or more (complex forms) calvarial sutures and represent the most frequent form of craniosynostosis worldwide. The etiology of NSC is still largely unknown as a genetic basis can be rarely demonstrated especially in single-suture forms. In these cases, during the prenatal/perinatal development of affected patients, only one suture undergoes a premature direct ossification within an otherwise physiologically grown skull. This could suggest that definite somatic alterations, possibly due to unclear environmental agents, occur locally at the site of premature suture fusion during skull development. A promising tool to investigate the molecular mechanisms that may orchestrate this event is the comparative analysis of suture- and synostosis-derived tissues and cells. PURPOSE: This review focuses on the different studies that attempted to clarify this issue using genome-wide microarray-based technologies for the comparative analysis of gene expression profiles. All relevant results have been comprehensively reviewed, possibly compared, and critically discussed.
conclusionDue to the heterogeneity of the dataset available in the literature, a univocal CRS-associated molecular profile could not be deciphered. Most differentially expressed genes are found in different studies to be involved in extracellular matrix remodeling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.