ReviewMammalian genome : official journal of the International Mammalian Genome Society2012
Genetic control of multiple births in low ovulating mammalian species.
Review in Mammalian genome : official journal of the International Mammalian Genome Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity.Human reproduction (Oxford, England) · 2024Pooled it
- Unravelling Twin Births in German Holstein Cows: Phenotypic Associations, Genetic Analysis and Potential Underlying Genes and Hormones.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Alanine Derived fromResearch (Washington, D.C.) · 2025Article
- Evolution of Litter Size: Proximate and Ultimate Mechanisms.Integrative and comparative biology · 2024Review
- Effect of post-mating administration of ketoprofen on serum progesterone concentration and fertility in Akkaraman ewes.Tropical animal health and production · 2024Article
- The effect of different doses of estradiol benzoate on follicle development and twin birth in beef cattle with induced superovulation.Archives animal breeding · 2024Article
- A gene-culture co-evolutionary perspective on the puzzle of human twinship.Evolutionary human sciences · 2024Article
- Effects of New Mutations inVeterinary sciences · 2023Article
- Article
- Favored single nucleotide variants identified using whole genome Re-sequencing of Austrian and Chinese cattle breeds.Frontiers in genetics · 2022Article
- A major QTL at the LHCGR/FSHR locus for multiple birth in Holstein cattle.Genetics, selection, evolution : GSE · 2021Article
- Thermal Mechanisms Preventing or Favoring Multiple Ovulations in Dairy Cattle.Animals : an open access journal from MDPI · 2021Review
- Genome Divergence and Dynamics in the Thin-Tailed Desert Sheep From Sudan.Frontiers in genetics · 2021Article
- Novel Variants inGenes · 2020Article
- Article
- Genetic selection against intrauterine growth retardation in piglets: a problem at the piglet level with a solution at the sow level.Genetics, selection, evolution : GSE · 2018Article
- Differential gene expression in ovaries of Qira black sheep and Hetian sheep using RNA-Seq technique.PloS one · 2015Article
- Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyperprolificacy phenotype in sheep.PLoS genetics · 2013Article
- The highly prolific phenotype of Lacaune sheep is associated with an ectopic expression of the B4GALNT2 gene within the ovary.PLoS genetics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals, litter size is a highly variable trait. Some species such as humans or cattle are monotocous, with one or sometimes two newborns per birth, whereas others, the polytocous species such as mice or pigs, are highly prolific and often produce a dozen newborns at each farrowing. In monotocous species, however, two or three newborns per birth may sometime be unwanted. In more polytocous species such as sheep or pigs, litter size is studied in order to increase livestock prolificacy. By contrast, twinning rates in humans or cattle may increase birth difficulties and health problems in the newborns. In this context, the aim of our review was to provide a clearer understanding of the genetic and physiological factors that control multiple births in low-ovulating mammalian species, with particular focus on three species: sheep, cattle, and humans, where knowledge of the ovulation rate in one may enlighten findings in the others. This article therefore reviews the phenotypic and genetic variability observed with respect to ovulation and twinning rates. It then presents the QTL and major genes that have been identified in each species. Finally, we draw a picture of the diversity of the physiological mechanisms underlying multiple ovulation. Although several major genes have been discovered in sheep, QTL detection methods in humans or cattle have suggested that the determinism of litter size is complex and probably involves several genes in order to explain variations in the number of ovulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.