ArticleDevelopment (Cambridge, England)2012
Anterior-posterior differences in HoxD chromatin topology in limb development.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 67 citations in OpenAlex.
- Neural regulation of H3K27me3 during the induction of patterning competency in regenerating Axolotl limb cells.Communications biology · 2025Article
- Loss of H3K9 trimethylation alters chromosome compaction and transcription factor retention during mitosis.Nature structural & molecular biology · 2023Article
- Chromatin accessibility: methods, mechanisms, and biological insights.Nucleus (Austin, Tex.) · 2022Review
- Zinc finger protein 277 is an intestinal transit-amplifying cell marker and colon cancer oncogene.JCI insight · 2022Article
- Transcriptional enhancers and their communication with gene promoters.Cellular and molecular life sciences : CMLS · 2021Review
- Extensive pleiotropism and allelic heterogeneity mediate metabolic effects ofScience (New York, N.Y.) · 2021Article
- Geminin is required for Hox gene regulation to pattern the developing limb.Developmental biology · 2020Article
- A central role for canonical PRC1 in shaping the 3D nuclear landscape.Genes & development · 2020Article
- Towards a comprehensive catalogue of validated and target-linked human enhancers.Nature reviews. Genetics · 2020Review
- Visualizing Genome Reorganization Using 3D DNA FISH.Methods in molecular biology (Clifton, N.J.) · 2020Article
- L-type voltage-gated CaProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Long-range interactions between proximal and distal regulatory regions in maize.Nature communications · 2019Article
- Chromatin folding and nuclear architecture: PRC1 function in 3D.Current opinion in genetics & development · 2019Review
- PKNOX2 expression and regulation in the bone marrow mesenchymal stem cells of Fanconi anemia patients and healthy donors.Molecular biology reports · 2019Article
- Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci.Cell reports · 2017Article
- Article
- Dynamic Control of X Chromosome Conformation and Repression by a Histone H4K20 Demethylase.Cell · 2017Article
- Multitasking by Polycomb response elements.Genes & development · 2017Article
- Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip.PLoS genetics · 2017Article
- Genome-wide mapping and analysis of chromosome architecture.Nature reviews. Molecular cell biology · 2016Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
A late phase of HoxD activation is crucial for the patterning and growth of distal structures across the anterior-posterior (A-P) limb axis of mammals. Polycomb complexes and chromatin compaction have been shown to regulate Hox loci along the main body axis in embryonic development, but the extent to which they have a role in limb-specific HoxD expression, an evolutionary adaptation defined by the activity of distal enhancer elements that drive expression of 5' Hoxd genes, has yet to be fully elucidated. We reveal two levels of chromatin topology that differentiate distal limb A-P HoxD activity. Using both immortalised cell lines derived from posterior and anterior regions of distal E10.5 mouse limb buds, and analysis in E10.5 dissected limb buds themselves, we show that there is a loss of polycomb-catalysed H3K27me3 histone modification and a chromatin decompaction over HoxD in the distal posterior limb compared with anterior. Moreover, we show that the global control region (GCR) long-range enhancer spatially colocalises with the 5' HoxD genomic region specifically in the distal posterior limb. This is consistent with the formation of a chromatin loop between 5' HoxD and the GCR regulatory module at the time and place of distal limb bud development when the GCR participates in initiating Hoxd gene quantitative collinearity and Hoxd13 expression. This is the first example of A-P differences in chromatin compaction and chromatin looping in the development of the mammalian secondary body axis (limb).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.