ArticleMenopause (New York, N.Y.)2012
Depressive symptoms are increased in the early perimenopausal stage in ethnically diverse human immunodeficiency virus-infected and human immunodeficiency virus-uninfected women.
Article in Menopause (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bone Density and Fractures in HIV-infected Postmenopausal Women: A Systematic Review.The Journal of the Association of Nurses in AIDS Care : JANACPooled it
- Substance use and menopausal hormone therapy: Treatment initiation and interruption among US women with and without HIV, 2008-2019.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Epidemiological Characteristics and Mental Health Disparities Between War-Displaced Ukrainian and Host-Country People Living with HIV in Slovakia: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Women with HIV transitioning through menopause: Insights from the Swiss HIV Cohort Study (SHCS).HIV medicine · 2022Article
- BAGEL: A BAYESIAN GRAPHICAL MODEL FOR INFERRING DRUG EFFECT LONGITUDINALLY ON DEPRESSION IN PEOPLE WITH HIV.The annals of applied statistics · 2022Article
- Pomegranate and Its Components, Punicalagin and Ellagic Acid, Promote Antidepressant, Antioxidant, and Free Radical-Scavenging Activity in Ovariectomized Rats.Frontiers in behavioral neuroscience · 2022Article
- How do women living with HIV experience menopause? Menopausal symptoms, anxiety and depression according to reproductive age in a multicenter cohort.BMC women's health · 2021Article
- Integrase Strand Transfer Inhibitor Start or Switch Impacts Learning in Women With HIV.Journal of acquired immune deficiency syndromes (1999) · 2021Article
- Associations between Antiretroviral Drugs on Depressive Symptomatology in Homogenous Subgroups of Women with HIV.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021Article
- Cognitive changes during the menopausal transition: a longitudinal study in women with and without HIV.Menopause (New York, N.Y.) · 2021Article
- Clinically Used Hormone Formulations Differentially Impact Memory, Anxiety-Like, and Depressive-Like Behaviors in a Rat Model of Transitional Menopause.Frontiers in behavioral neuroscience · 2021Article
- Bipolar Disorder in the Menopausal Transition.Current psychiatry reports · 2019Review
- In people living with HIV (PLWH), menopause (natural or surgical) contributes to the greater symptom burden in women: results from an online US survey.Menopause (New York, N.Y.) · 2018Article
- Association between HIV status and psychological symptoms in perimenopausal women.Menopause (New York, N.Y.) · 2018Article
- Severe menopausal symptoms associated with reduced adherence to antiretroviral therapy among perimenopausal and menopausal women living with HIV in Metro Vancouver.Menopause (New York, N.Y.) · 2018Article
- Elevated stress is associated with prefrontal cortex dysfunction during a verbal memory task in women with HIV.Journal of neurovirology · 2016Article
- Prefrontal cortical volume loss is associated with stress-related deficits in verbal learning and memory in HIV-infected women.Neurobiology of disease · 2016Article
- Perspectives on menopause and women with HIV.International journal of women's health · 2016Review
- Perimenopause as a neurological transition state.Nature reviews. Endocrinology · 2015Review
- Increased hot flash severity and related interference in perimenopausal human immunodeficiency virus-infected women.Menopause (New York, N.Y.) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveThe risk of clinically significant depressive symptoms increases during perimenopause. With highly active antiretroviral treatment (HAART), more human immunodeficiency virus (HIV)-infected women survive to transition through menopause. In a cross-sectional analysis, we evaluated the association of menopausal stage and vasomotor symptoms with depressive symptoms in an ethnically diverse cohort of women with a high prevalence of HIV.
methodsParticipants included 835 HIV-infected women and 335 HIV-uninfected controls from the Women's Interagency HIV Study (63% African American). The Center for Epidemiologic Studies Depression Scale was used to screen for elevated depressive symptoms. Menopausal stages were defined according to standard definitions. Logistic regression analysis was used to identify predictors of elevated depressive symptoms.
resultsCompared with premenopausal women, early perimenopausal women (OR [odds ratio], 1.74; 95% CI, 1.17-2.60), but not late perimenopausal or postmenopausal women, were more likely to show elevated depressive symptoms in adjusted analyses. The odds were similar in HIV-infected and HIV-uninfected women. Persistent vasomotor symptoms also predicted elevated depressive symptoms in HIV-infected and HIV-uninfected women (OR, 1.45; 95% CI, 1.02-2.06). In HIV-infected women, menopausal stage interacted with antiretroviral use (P = 0.02); the likelihood of elevated depressive symptoms in early perimenopause compared with premenopause was especially high in HAART-untreated women (OR, 3.87; 95% CI, 1.57-9.55).
conclusionsIn HIV-infected and HIV-uninfected women, the odds of elevated depressive symptoms were significantly higher during early perimenopause. Elevated depressive symptoms were associated with nonadherence to HAART, underscoring the importance of screening and treating depressive symptoms in HIV-infected women who have experienced a change in the regularity of their menstrual cycles.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.