ArticleAnnals of Saudi medicine
Vitamin D insufficiency and deficiency in children with chronic kidney disease.
Article in Annals of Saudi medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Is high-dose cholecalciferol justified in children with chronic kidney disease who failed low-dose maintenance therapy?Pediatric nephrology (Berlin, Germany) · 2013Trial
- Assessing Vascular Biomarkers and Their Association with Hypertension in Paediatric Chronic Kidney Disease.Sultan Qaboos University medical journal · 2025Article
- Vitamin D: are all compounds equal?Clinical kidney journal · 2025Article
- The clinical relevance of native vitamin D in pediatric kidney disease.Pediatric nephrology (Berlin, Germany) · 2023Review
- Native vs. active vitamin D in children with chronic kidney disease: a cross-over study.Pediatric nephrology (Berlin, Germany) · 2021Article
- Clinical practice recommendations for native vitamin D therapy in children with chronic kidney disease Stages 2-5 and on dialysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017Article
- Prevalence of Hyperparathyroidism, Mineral and Bone Disorders in Children with Advanced Chronic Kidney Disease.Indian journal of pediatrics · 2016Observational
- Comment on "clinicians should be more prone to examine children with chronic kidney disease in terms of vitamin D deficiency".Annals of Saudi medicineArticle
- Early predictors of cardiac dysfunction in Egyptian children with chronic kidney disease.Annals of pediatric cardiologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesHypovitaminosis D is a frequent condition in normal populations. Children with chronic kidney disease (CKD) present a high risk of developing complications due to hypovitaminosis D. Our aim was to determine the frequency of vitamin D insufficiency/deficiency in children with different stages of CKD who were followed up at King Abdulaziz University Hospital (KAUH), Jeddah, Saudi Arabia. DESIGN AND
settingUniversity hospital-based case-control study of children followed up between March 2010 and March 2011. PATIENTS AND
methodsBlood was extracted from children with CKD to measure urea, creatinine, hemoglobin, calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone (iPTH), and vitamin D3 levels. We calculated correlations between iPTH and vitamin D levels, and associations between vitamin D levels and CKD stages.
resultsThe frequency of vitamin D insufficiency/deficiency was high among the cases and controls. Children with CKD had significantly lower levels of vitamin D than their peers with normal kidney function (P=.05) with a mean (SD) level of 17.5 (9.9) ng/mL versus 21.0 (13.4) ng/mL for the control group. Among the children with CKD, 36 (45.0%) had vitamin D insufficiency, 24 (30.0%) had vitamin D deficiency, and 10 (12.5%) had severe deficiency. There was a positive correlation between vitamin D3 level and CKD stages (Kendall tau=0.22, P=.003). A significant association existed between glomerular filtration rate and vitamin D3 deficiency (P=.002). There was a significant negative correlation between iPTH and vitamin D3 concentrations (Spearman correlation coefficient= -0.27, P=.01). A significant association existed between age and vitamin D3 level (P < .0001).
conclusionVitamin D insufficiency/deficiency is more frequent in children with CKD than in those with normal kidney function.
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