Evidence map›Paper›PMID 22871580›Full record

ArticleBioorganic & medicinal chemistry letters2012

Near-infrared fluorescent divalent RGD ligand for integrin αvβ₃-targeted optical imaging.

Yunpeng Ye, Walter Akers, Baogang Xu, Sharon Bloch, Charles Odonkor, Samuel Achilefu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yunpeng YeDepartment of Radiology, Optical Radiology Laboratory, Washington University School of Medicine, 4525 Scott Avenue, Saint Louis, MO 63108, USA.
Walter Akers
Baogang Xu
Sharon Bloch
Charles Odonkor
Samuel Achilefu

Funding

Optical Probes &Methods for Imaging Integrin ExpressionR01CA109754 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2004 to 2008
$2.9M
MOLECULAR PROBES AND METHODS FOR FLUORESCENCE LIFETIME TOMOGRAPHY AND MICROSCOPYR01EB008111 · NIBIB · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2009 to 2012
$1.9M
NEAR INFRARED PH-SENSITIVE MOLECULAR PROBES FOR MICROSCOPY OF CELLS AND TISSUESR01EB007276 · NIBIB · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2008 to 2011
$1.3M
Multiphoton microscopy using near infrared DyesR33CA123537 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2008 to 2010
$1.3M
NCI NIH HHS R01 CA109754NCI NIH HHS R33 CA123537NIBIB NIH HHS R01 EB007276NIBIB NIH HHS R01 EB008111
6 · The paper itself

Abstract

A new near-infrared fluorescent compound containing two cyclic RGD motifs, cypate-[c(RGDfK)](2) (1), was synthesized based on a carbocyanine fluorophore bearing two carboxylic acid groups (cypate) for integrin α(v)β(3)-targeting. Compared with its monovalent counterpart cypate-c(RGDfK) (2), 1 exhibited remarkable improvements in integrin α(v)β(3) binding affinity and tumor uptake in nude mice of A549. The results suggest that cypate-linked divalent ligands can serve as an important molecular platform for exploring receptor-targeted optical imaging and treatment of various diseases.

Indexed as

AnimalsCarbocyaninesCell Line, TumorFluorescent DyesHumansIntegrin alphaVbeta3MiceMice, NudeNeoplasmsOligopeptidesOptical Imagingarginyl-glycyl-aspartic acidCarbocyaninesFluorescent DyesIntegrin alphaVbeta3Oligopeptides

Identifiers

PMID22871580
PMCPMC3423536

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.