ArticleThe American journal of pathology2012
Determination of severity of murine IgA nephropathy by glomerular complement activation by aberrantly glycosylated IgA and immune complexes.
Article in The American journal of pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- A Phase 2 Trial of Sibeprenlimab in Patients with IgA Nephropathy.The New England journal of medicine · 2024Trial
- Serum under-O-glycosylated IgA1 level is not correlated with glomerular IgA deposition based upon heterogeneity in the composition of immune complexes in IgA nephropathy.BMC nephrology · 2014Trial
- Effects of Atrasentan on Kidney Gene Transcription, Mesangial Cell Proliferation, and Proteinuria in IgA Nephropathy.Kidney360 · 2026Article
- Plasmacytoid dendritic cells modulate the production of mucosal IgA in IgA nephropathy.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Article
- B Cell Activating Factor Does Not Play a Pivotal Role in the Synthesis of Aberrantly Glycosylated IgA.Nephrology (Carlton, Vic.) · 2025Article
- Lessons from IgA Nephropathy Models.International journal of molecular sciences · 2024Review
- Targeting the Endothelin A Receptor in IgA Nephropathy.Kidney international reports · 2023Review
- Crescents and IgA Nephropathy: A Delicate Marriage.Journal of clinical medicine · 2022Review
- Crescents in primary glomerulonephritis: a pattern of injury with dissimilar actors. A pathophysiologic perspective.Pediatric nephrology (Berlin, Germany) · 2022Review
- Hyposialylation Must Be Considered to Develop Future Therapies in Autoimmune Diseases.International journal of molecular sciences · 2021Review
- Experimental evidence of pathogenic role of IgG autoantibodies in IgA nephropathy.Journal of autoimmunity · 2021Article
- Complement activation is associated with crescent formation in IgA nephropathy.Virchows Archiv : an international journal of pathology · 2020Article
- A novel immunochromatographic strips assay for rapid and simple detection of systemic lupus erythematosus.Scientific reports · 2020Article
- Pathological application of carbocyanine dye-based multicolour imaging of vasculature and associated structures.Scientific reports · 2020Article
- Interleukin-17 promotes the production of underglycosylated IgA1 in DAKIKI cells.Renal failure · 2018Article
- Underweight Is an Independent Risk Factor for Renal Function Deterioration in Patients with IgA Nephropathy.PloS one · 2016Article
- Enhanced auto-antibody production and Mott cell formation in FcμR-deficient autoimmune mice.International immunology · 2014Article
- Uncoupling of glomerular IgA deposition and disease progression in alymphoplasia mice with IgA nephropathy.PloS one · 2014Article
- Changes in nephritogenic serum galactose-deficient IgA1 in IgA nephropathy following tonsillectomy and steroid therapy.PloS one · 2014Article
- IgA Nephropathy with Pathologic Features of Membranoproliferative Glomerulonephritis following Burn Injury.Case reports in nephrology and urology · 2014Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
The pathogenic roles of glomerular deposition of components of the complement cascade in IgA nephropathy (IgAN) are not completely clarified. To investigate the pathologic role of complement pathways in IgAN, two IgAN-prone mouse models were examined. Grouped ddY (gddY) mice showed significant high proteinuria, severe glomerular lesions, and extracellular matrix expansion compared with high serum IgA (HIGA) mice but with similar intensity of glomerular IgA deposition. Glomerular activation of the classical, lectin, and alternative pathways was demonstrated by significantly stronger staining for complement (C)3, C5b-9, C1q, C4, mannose-binding lectin (MBL)-A/C, MBL-associated serine protease-2, and factor B and properdin in gddY mice than in HIGA mice. Similarly, the serum levels of IgA-IgG2a/IgM and IgA-MBL-A/C immune complexes and polymeric IgA were significantly higher in gddY mice than in HIGA mice. Moreover, the serum levels of aberrantly glycosylated IgA characterized by the binding of Sambucus nigra bark lectin and Ricinus communis agglutinin I were significantly higher in gddY mice than in HIGA mice. This aberrancy in glycosylation was confirmed by monosaccharide compositional analysis of purified IgA using gas-liquid chromatography. This study is the first to demonstrate that aberrantly glycosylated IgA may influence the formation of macromolecular IgA including IgA-IgG immune complexes and subsequent complement activation, leading to full progression of IgAN.
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