Trial reportMechanisms of ageing and development
Genotype×age interaction in human transcriptional ageing.
Trial report in Mechanisms of ageing and development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- The transcriptional landscape of age in human peripheral blood.Nature communications · 2015Pooled it
- Review
- Effects of aging on gene expression networks in the Drosophila genetic reference panel.Cell reports · 2025Article
- Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection.Nature communications · 2023Article
- Genetic influence on cognitive development between childhood and adulthood.Molecular psychiatry · 2021Article
- Immune-Related Genetic Overlap Between Regional Gray Matter Reductions and Psychiatric Symptoms in Adolescents, and Gene-Set Validation in a Translational Model.Frontiers in systems neuroscience · 2021Article
- Genetic regulation of gene expression and splicing during a 10-year period of human aging.Genome biology · 2019Article
- OSCA: a tool for omic-data-based complex trait analysis.Genome biology · 2019Article
- The widespread increase in inter-individual variability of gene expression in the human brain with age.Aging · 2019Article
- The RNA world of human ageing.Human genetics · 2018Review
- Genetic and environmental (physical fitness and sedentary activity) interaction effects on cardiometabolic risk factors in Mexican American children and adolescents.Genetic epidemiology · 2018Article
- Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort.Human molecular genetics · 2018Article
- Time-dependent genetic effects on gene expression implicate aging processes.Genome research · 2017Article
- Renin-angiotensin-aldosterone system gene polymorphisms in gestational hypertension and preeclampsia: A case-control gene-association study.Scientific reports · 2016Article
- Circulating microRNA signature of genotype-by-age interactions in the long-lived Ames dwarf mouse.Aging cell · 2015Article
- Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases.Scientific reports · 2015Article
- Sex- and age-interacting eQTLs in human complex diseases.Human molecular genetics · 2014Article
- Genetic basis of neurocognitive decline and reduced white-matter integrity in normal human brain aging.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Gene expression changes with age in skin, adipose tissue, blood and brain.Genome biology · 2013Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
Individual differences in biological ageing (i.e., the rate of physiological response to the passage of time) may be due in part to genotype-specific variation in gene action. However, the sources of heritable variation in human age-related gene expression profiles are largely unknown. We have profiled genome-wide expression in peripheral blood mononuclear cells from 1240 individuals in large families and found 4472 human autosomal transcripts, representing ~4349 genes, significantly correlated with age. We identified 623 transcripts that show genotype by age interaction in addition to a main effect of age, defining a large set of novel candidates for characterization of the mechanisms of differential biological ageing. We applied a novel SNP genotype × age interaction test to one of these candidates, the ubiquilin-like gene UBQLNL, and found evidence of joint cis-association and genotype by age interaction as well as trans-genotype by age interaction for UBQLNL expression. Both UBQLNL expression levels at recruitment and cis genotype are associated with longitudinal cancer risk in our study cohort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.