ArticleBMC research notes2012
Diagnosis of latent tuberculosis infection in healthy young adults in a country with high tuberculosis burden and BCG vaccination at birth.
Article in BMC research notes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Mycobacterium tuberculosis latent infection in healthcare students: systematic review of prevalence.Revista da Escola de Enfermagem da U S P · 2024Pooled it
- The effect of maternal helminth infection on maternal and neonatal immune function and immunity to tuberculosis.PloS one · 2014Trial
- Article
- A tuberculin skin test survey among healthcare workers in two public tertiary care hospitals in Bangladesh.PloS one · 2020Article
- Does Isoniazid Preventive Therapy Provide Better Treatment Outcomes in HIV-Infected Individuals in Northern Ethiopia? A Retrospective Cohort Study.AIDS research and treatment · 2020Article
- Latent tuberculosis infection and associated risk indicators in pastoral communities in southern Ethiopia: a community based cross-sectional study.BMC public health · 2018Article
- Immigrant screening for latent tuberculosis in Norway: a cost-effectiveness analysis.The European journal of health economics : HEPAC : health economics in prevention and care · 2017Article
- Detection of latent tuberculosis infection among migrant farmworkers along the US-Mexico border.BMC infectious diseases · 2016Article
- Prevalence and risk factors of latent Tuberculosis among adolescents in rural Eastern Uganda.African health sciences · 2015Article
- Interferon Gamma-Based Detection of Latent Tuberculosis Infection in the Border States of Nuevo Leon and Tamaulipas, Mexico.Frontiers in public health · 2015Article
- Performance of a rapid strip test for the serologic diagnosis of latent tuberculosis in children.Journal of clinical and diagnostic research : JCDR · 2015Article
- Helminth infection increases the probability of indeterminate QuantiFERON gold in tube results in pregnant women.BioMed research international · 2014Article
- [Factors associated with treatment adherence for tuberculosis infection].Atencion primaria · 2014Observational
- Infection control knowledge, attitudes, and practices among healthcare workers in Addis Ababa, Ethiopia.Infection control and hospital epidemiology · 2013Article
- Parasitic infection may be associated with discordant responses to QuantiFERON and tuberculin skin test in apparently healthy children and adolescents in a tuberculosis endemic setting, Ethiopia.BMC infectious diseases · 2013Article
- Prevalence and correlates ofClinical epidemiology and global healthArticle
- Prevalence of latent tuberculosis infection and risk of infection in patients with chronic kidney disease undergoing hemodialysis in a referral center in Brazil.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e TisilogiaArticle
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOne third of the world's population is thought to have latent tuberculosis infection (LTBI) with the potential for subsequent reactivation of disease. To better characterize this important population, studies comparing Tuberculin Skin Test (TST) and the new interferon-γ release assays including QuantiFERON®-TB Gold In-Tube (QFT-GIT) have been conducted in different parts of the world, but most of these have been in countries with a low incidence of tuberculosis (TB). The aim of this study was therefore to evaluate the use of QFT-GIT assay as compared with TST in the diagnosis of LTBI in Ethiopia, a country with a high burden of TB and routine BCG vaccination at birth.
methodsHealthy medical and paramedical male students at the Faculty of Medicine, Addis Ababa University, Ethiopia were enrolled into the study from December 2008 to February 2009. The TST and QFTG-IT assay were performed using standard methods.
resultsThe mean age of the study participants was 20.9 years. From a total of 107 study participants, 46.7% (95%CI: 37.0% to 56.6%) had a positive TST result (TST≥10 mm), 43.9% (95%CI: 34.3% to 53.9%) had a positive QFT-GIT assay result and 44.9% (95%CI: 35.2% to 54.8%) had BCG scar. There was strong agreement between TST (TST ≥10mm) and QFT-GIT assay (Kappa = 0.83, p value = 0.000).
conclusionThe TST and QFT-GIT assay show similar efficacy for the diagnosis of LTBI in healthy young adults residing in Ethiopia, a country with high TB incidence.
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