SynthesisBMC psychiatry2012
Structural brain changes in First Episode Schizophrenia compared with Fronto-Temporal Lobar Degeneration: a meta-analysis.
Synthesis in BMC psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Psychosis in multiple sclerosis-a narrative review of an underestimated, but clinically significant problem.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Exploring Links Between Psychosis and Frontotemporal Dementia Using Multimodal Machine Learning: Dementia Praecox Revisited.JAMA psychiatry · 2022Article
- Grey and white matter associations of psychotic-like experiences in a general population sample (UK Biobank).Translational psychiatry · 2021Article
- Application of Graph Theory to Assess Static and Dynamic Brain Connectivity: Approaches for Building Brain Graphs.Proceedings of the IEEE. Institute of Electrical and Electronics Engineers · 2018Article
- Glutamatergic Metabolites, Volume and Cortical Thickness in Antipsychotic-Naive Patients with First-Episode Psychosis: Implications for Excitotoxicity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Article
- Age at First Episode Modulates Diagnosis-Related Structural Brain Abnormalities in Psychosis.Schizophrenia bulletin · 2016Article
- Altered activation of innate immunity associates with white matter volume and diffusion in first-episode psychosis.PloS one · 2015Article
- Distribution of tract deficits in schizophrenia.BMC psychiatry · 2014Article
- Interactive 3D visualization of structural changes in the brain of a person with corticobasal syndrome.Frontiers in neuroinformatics · 2014Article
- Neuroimaging schizophrenia: a picture is worth a thousand words, but is it saying anything important?Current psychiatry reports · 2013Review
- Brain connectivity networks in schizophrenia underlying resting state functional magnetic resonance imaging.Current topics in medicinal chemistry · 2012Review
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe authors sought to compare gray matter changes in First Episode Schizophrenia (FES) compared with Fronto-Temporal Lobar Degeneration (FTLD) using meta-analytic methods applied to neuro-imaging studies.
methodsA systematic search was conducted for published, structural voxel-based morphometric MRI studies in patients with FES or FTLD. Data were combined using anatomical likelihood estimation (ALE) to determine the extent of gray matter decreases and analysed to ascertain the degree of overlap in the spatial distribution of brain changes in both diseases.
resultsData were extracted from 18 FES studies (including a total of 555 patients and 621 comparison subjects) and 20 studies of FTLD or related disorders (including a total of 311 patients and 431 comparison subjects). The similarity in spatial overlap of brain changes in the two disorders was significant (p = 0.001). Gray matter deficits common to both disorders included bilateral caudate, left insula and bilateral uncus regions.
conclusionsThere is a significant overlap in the distribution of structural brain changes in First Episode Schizophrenia and Fronto-Temporal Lobar Degeneration. This may reflect overlapping aetiologies, or a common vulnerability of these regions to the distinct aetio-pathological processes in the two disorders.
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